The CRC Handbook of Chemistry and Physics is a comprehensive one-volume reference resource for science research, currently in its 96th edition. It is sometimes nicknamed the 'Rubber Bible' or the 'Rubber Book', as CRC originally stood for "Chemical Rubber Company".

As late as the 1962–1963 edition (3,604 pages) the Handbook contained myriad information for every branch of science and engineering. Sections in this edition includes; Mathematics, Properties and Physical Constants, Chemical Tables, Properties of Matter, Heat, Hygrometric and Barometric Tables, Sound, Quantities and Units, and Miscellaneous. There are such prosaic subjects as; "Antidotes of Poisons", "Rules for Naming Organic Compounds", "Surface Tension of Fused Salts", "Percent Composition of Anti-Freeze Solutions", "Spark-gap Voltages", "Greek Alphabet", "Musical Scales", "Pigments and Dyes", "Comparison of Tons and Pounds", "Twist Drill and Steel Wire Gauges" and "Properties of the Earth's Atmosphere at Elevations up to 160 Kilometers". Later editions focus almost exclusively on Chemistry and Physics topics and eliminated much of the more "common" information.