Papers by Stefano Bonassi
Experimental and Therapeutic Medicine, 2012
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Annals of Occupational Hygiene, 2003
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Minerva pediatrica, 2006
In 1982, 60 children affected by acute lymphoblastic leukemia, treated between 1974 and 1978 with... more In 1982, 60 children affected by acute lymphoblastic leukemia, treated between 1974 and 1978 with or without cranial radiation, in complete remission, and 2 years at least after stopping therapy, were submitted to a detailed psychological investigation. All those who underwent cranial radiation showed memory impairment. Twenty years after, 49 of them were still alive. On the occasion of the 30th Anniversary of the Department, we contacted their parents and invited them to an encounter: 43 agreed. We wished to learn as much as possible about their current health and psychosocial status. The principal aim of our research was to investigate if any differences existed between the 2 groups and to measure the psychosocial performance of these subjects against comparable Italian figures extracted from the last national census (Census 2001). We chose the narrative style for the encounters, because most of them knew about us only from their parents, and we were afraid to use with them questi...
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International Journal of Adolescent Medicine and Health, 2015
Abstract Background: Adolescents affected by a severe disease who undergo high-risk treatment may... more Abstract Background: Adolescents affected by a severe disease who undergo high-risk treatment may experience stress, pain, extreme frustration, depression, and anger. In this large spectrum of emotions, several situations must be considered carefully. To improve coping and quality of services offered to adolescents in paediatric hospitals, we elaborated a semi-structured interview and a short questionnaire (Quality of life-adolescent-Istituto Giannina Gaslini, QoL-adol-IGG scale) to investigate the quality of life, the needs and expectations of adolescent in-patients. Methods: The study sample includes 117 in-patients aged between 10 and 20 years coming from several Italian regions who were admitted to the G. Gaslini Research Children's Hospital for a period of 10 days or more, regardless of the disease. The QoL-adol-IGG scale was administered - after obtaining informed consent from the children and their parents - in one single encounter by trained psychologist. The distribution of the answers was evaluated after stratification by patient's age, gender, area of residence, and clinical diagnosis. Continuous data were compared using the Kruskal-Wallis, while the χ2-test was used for categorical data. Results: Seventy-two percent had difficulty practicing normal daily activities during their stay in the hospital, not only because of the disease (40%), but also because of the poor organization within the hospital, the lack of proposals/activities and space for spare time, and the limited access to technologies. Adolescents ≥15 years were more frequently dissatisfied than youngsters concerning the access to Internet and other technologies, the possibility to make new friends and to take part in social activities. Conclusion: The results of this study, which evaluated the hospital's organization, but also psychological functioning in a representative sample of patients, may contribute to optimize internal procedures of clinical departments where adolescent in-patients are present, on the basis of their requests and taking into account their age.
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Diabetes Care, 1994
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Cancer Research, Sep 15, 1998
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Mutagenesis, 2011
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Cancer Epidemiology Biomarkers Prevention, 2009
In the November 2008 article (1) on the CREST biore-pository on respiratory tract cancer, the cor... more In the November 2008 article (1) on the CREST biore-pository on respiratory tract cancer, the correct names of the authors are as follows: Donatella Ugolini, Monica Neri, Pier Aldo Canessa, Cristina Casilli, Giuseppe Catrambone, Giovanni Paolo Ivaldi, Cecilia Lando, ...
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Age and ageing, Jan 11, 2015
persons who are 65 years or older often spend an important part of their lives indoors thus adver... more persons who are 65 years or older often spend an important part of their lives indoors thus adverse indoor climate might influence their health status. to evaluate the influence of indoor air quality and contaminants on older people's respiratory health. cross-sectional study. 21 long-term care residences (LTC) in the city of Porto, Portugal. older people living in LTC with ≥65 years old. the Portuguese version of BOLD questionnaire was administered by an interviewer to older residents able to participate (n = 143). Indoor air contaminants (IAC) were measured twice, during winter and summer in 135 areas. Mixed effects logistic regression models were used to study the association between the health questionnaire results and the monitored IAC, adjusted for age, smoking habits, gender and number of years living in the LTC. cough (23%) and sputum (12%) were the major respiratory symptoms, and allergic rhinitis (18%) the main self-reported illness. Overall particulate matter up to 2....
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Current medicinal chemistry, Jan 4, 2015
Respiratory diseases including chronic-obstructive-pulmonary-disease (COPD) are globally increasi... more Respiratory diseases including chronic-obstructive-pulmonary-disease (COPD) are globally increasing, with COPD predicted to become the third leading cause of global mortality by 2020. COPD is a heterogeneous disease with COPD-patients displaying different phenotypes as the results of a complex interaction between various genetic, environmental and life-style factors. Several investigations in last years have been performed to better define such interactions but the identification of resulting phenotypes is still somewhat difficult, and may result in inadequate assessment and management of COPD (usually solely based on the severity of airflow-limitation (FEV1). In this new scenario, the management of COPD has been drove towards an integrative and holistic approach. The degree of complexity requires analyses based on large datasets (including also advanced functional genomic-assay) and novel computational biology approaches (essential to extract information relevant for the clinical d...
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Journal of the American Medical Directors Association, Jan 30, 2015
In older adults co-occurrence of multiple diseases often leads to use of multiple medications (po... more In older adults co-occurrence of multiple diseases often leads to use of multiple medications (polypharmacy). The aim of the present study is to describe how prescription of medications varies across age groups, with specific focus on the oldest old. We performed a cross-sectional study using 2013 data from the OsMed Health-DB database (mean number of medicines and defined daily doses prescribed in 15,931,642 individuals). There were 3,378,725 individuals age 65 years or older (21.2% of the study sample). The mean number of prescribed medications progressively rose from 1.9 in the age group <65 years to 7.4 in the age group 80-84 years and then declined, with a more marked reduction in the age group 95 years or older with a mean number of 2.8 medications. A similar pattern was observed for the mean number of defined daily doses. Among participants age ≥65 years, proton pump inhibitors were the most commonly prescribed medication (40.9% of individuals ≥65 years), followed by plate...
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1988 Puntoni R, DF Goldsmith, F Valerio, M Vercelli, S Bonassi, F DiGiorgio, M Ceppi, E Stagnaro, R Filiberti, L Santi, and F Merlo. A cohort study of workers employed in refractory brick plant. Tumori 74: 27-33 Tumori
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Neoplasma
A descriptive study aimed at comparing mortality and dietary patterns in Italy and the Czech Repu... more A descriptive study aimed at comparing mortality and dietary patterns in Italy and the Czech Republic was conducted in the period 1970-1990. Mortality from all causes, all cancers, selected site specific cancers and cardiovascular diseases were found to be generally higher in the Czech Republic than in Italy. The North-South gradients observed within Italy have diminished in the course of the last twenty years, mostly due to a less contained decrease of the mortality from cardiovascular diseases and to a marked increase in cancer mortality for Southern regions compared to Central and Northern regions. The mediterranean diet with many health promoting, possibly protective components, mostly of vegetable origin, is consumed in most parts of Italy, particularly in the South. In contrast, a Central European diet abounding in animal products and lacking in fresh fruit and vegetables is generally followed in the Czech Republic. These differences in diet may play a role in the origin of th...
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Mutation Research/Reviews in Mutation Research, 2015
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International Journal of Hygiene and Environmental Health, 2015
Leukemia/lymphoma cases reported in 2001 among United Nation soldiers or peacekeepers deployed to... more Leukemia/lymphoma cases reported in 2001 among United Nation soldiers or peacekeepers deployed to the Balkans aroused alert on the exposure to depleted uranium. Recent epidemiological studies carried out in different European countries among peacekeepers who served in the Balkans failed to demonstrate a higher than expected risk of all cancers but, mostly due to their limitations in size and follow up time, leave open the debate on health risk of depleted uranium. The aim of SIGNUM (Study of the Genotoxic Impact in Military Units) was to identify potential genotoxic risk associated with the exposure to depleted uranium or other pollutants in the Italian Army military personnel deployed in Iraq. Blood and urine samples were collected before and after the deployment from 981 Italian soldiers operating in Iraq in 2004-2005. As, Cd, Mo, Ni, Pb, U, V, W, and Zr were determined in urine and serum. DNA-adducts, 8-hydroxy-2&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;-deoxyguanine and micronuclei frequency were evaluated in blood lymphocytes. Three different genetic polymorphisms, GSTM1, XRCC1, OGG1 were analyzed. Significant T0-T1 reduction in the total concentration of uranium, increases for Cd, Mo, Ni, Zr, and decreases for As, Pb, W, and V in urine and plasma were observed. Increases in oxidative alterations and in micronuclei frequency, included in the range of values of non-occupationally exposed populations, were observed at the end of the period of employment. Our results did not detect any toxicologically relevant variation of DNA-damage biomarkers related to the deployment in the operational theater.
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Papers by Stefano Bonassi