Papers by Sinai W . Mohammed
AIP Conference Proceedings, Dec 31, 2022
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Biomedical and Pharmacology Journal, Sep 29, 2023
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Baghdad Science Journal, 2011
This study was carried out in order to determine the toxic, mutagenic and antimutagenic effects f... more This study was carried out in order to determine the toxic, mutagenic and antimutagenic effects for Mallow (Malva parviflora) in comparison to its mutagenic effect of Ultraviolet (UV) because it is consider physical mutagen by using parameters for the extract pri , with , post UV exposure by using bacterial system (G-system). The used system consisted of three isolates G3 Bacillus spp., G12 Arthrobacter spp. and G27 Brevibacterium spp.. The study depended on recording survival fraction (Sx) for studying the effects and induction of Streptomycin and Refampicin resistance mutants as a genetic markers.Water Extract was prepared from fresh and dry mallow leaves, stems, flowers and roots, in optimum concentration equal to (125µg/ml) which is considered a negative control.The interactions included three types of treatments (pre, with and post –UV exposure) as a physical mutagen in order to determine the activity of this plant extracts in preventing or reducing the toxicity of the mutagen....
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Baghdad Science Journal, 2011
A total of 37 Staphylococcus epidermidis isolates, isolated from corneal scraping of patients wit... more A total of 37 Staphylococcus epidermidis isolates, isolated from corneal scraping of patients with bacterial keratitis and 20 isolates from healthy eyes (as control) (all isolates, isolated from, Ibn Al- Haietham eye hospital / Baghdad), were tested for slime production, 52.63% of all isolates were positive-slime production (23 isolates from patients and 7 isolates from controls). It was found that positive-slime producing S. epidermidis were exhibited a high resistance to antibiotics as compared to negative-slime producing isolates.
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Research Square (Research Square), Jun 7, 2022
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Revue Française d'Allergologie, 2021
Abstract Background Indoor allergens are important components of airborne allergens, and studies ... more Abstract Background Indoor allergens are important components of airborne allergens, and studies have linked allergic respiratory diseases (ARDs) and exposure to aeroallergens. Objectives This study sought to identify fungi in house dust from four regions in Baghdad city, and to assess the risks of ARD and asthma associated with indoor fungi. Methods House dust was collected from 84 homes located in four major areas in Baghdad; locations 1, 2, 3 and 4 (north, west, south-west and south of Baghdad, respectively). The dust samples were cultured to identify fungal genera. Results Seventy-nine mold isolates belong to nine genera (Aspergillus, Rhizopus, Penicillium, Chrysonilia, Mucor, Fusarium, Cladosporium, Alternaria and Helminthosporium), as well as five yeast isolates, were identified. Aspergillus was the most common type of mold (56.0%), while Alternaria and Helminthosporium were the least frequent (each with 1%). The distribution of these fungi showed variation according to location, but the difference was not significant. ARD in general and asthma in particular were detected in 50.0 and 14.3% of households, respectively. Both types of allergy were significantly associated with mold genera and with the number of households and rooms, as well as the availability of gardens and trees. Conclusions The study indicated that fungi are significant indoor determinants of ARD and asthma in the city of Baghdad.
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Journal of Biotechnology Research Center, 2011
his study was carried out in order to determine the toxic and mutagenic and antimutagenic effects... more his study was carried out in order to determine the toxic and mutagenic and antimutagenic effects for Mallow (Malva parviflora) against the mutagenic effect of Methotrexate (MTX).The effect was studied in a bacterial system (G-system). The used system consisted of three isolates G3 Bacillus spp, G12 Arthrobacter spp and G27 Brevibacterium spp. The study depended on recording survival fraction (Sx) as an indicator for the induction of Streptomycin and Refampicin resistance mutants as a genetic marker. Water Extract was prepared from fresh and dry mallow leaves, stems, flowers and roots Gradual concentrations of plant water extracts were use to choose the suitable concentration which is remembered the negative control. The interactions included three types of treatments (pre - MTX, with- MTX and post-MTX) as a chemical mutagen in order to determine the mechanisms of this plant extracts in preventing or reducing the genotoxic effect of MTX. The results showed that the interaction effec...
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Biomedical and Pharmacology Journal, 2018
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral mucosa. Hum... more Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral mucosa. Human papillomavirus (HPV) virus cause a broad scope of diseases from benign to invasive tumors, types 16 and 18 classified as carcinogenic to humans. This study aimed to provide the first molecular characterization of HPV types in Iraq. Thirty-five unstimulated whole saliva samples were collected from histopathologically confirmed patients with oral cancer were enrolled in this study. Genomic DNA was extracted from exfoliating cells to amplify HPV-DNA using HPV-L1 gene sequence primers by polymerase chain reaction method (PCR), the viral genotyping was performed using direct sequencing method. HPV genotypes identified were deposited in GenBank. HPV DNA was detected in 20 of 35 OSCC patients representing (57%).The most frequent HPV genotypes were HPV-18 accounting for (75%) (15 out of 20 patients) followed by HPV-16 accounting for (20%) (4 out of 20), and HPV-11 accounting for (5%) (5 out o...
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University of Thi-Qar Journal of Science
Dissimilar to all other pandemics in the past five decades, the humanity has been ravaged by the ... more Dissimilar to all other pandemics in the past five decades, the humanity has been ravaged by the coronavirus disease COVID-19. Starting from its outbreak, the disease's understanding has advanced quickly; multi-organ involvement is the key factor affecting the prognosis of the disease. Mortality and morbidity are closely related to acute respiratory distress syndrome, renal failure, cardiac failure, liver damage, multi-organ failure, and shock. In the initial phases of viral infection, detecting and controlling pro-inflammatory responses are essential. Throughout patient monitoring, it's crucial to consider the COVID-19 treatment's unknowable response. It has been discovered that IL-6 is causally linked to greater mortality. It is a reliable indicator regarding the progression of clinical profile as well as the prognosis of the disease. A highly important cytokine, after the activated macrophages, is it. As a result, a measure for COVID-19 could be the control regarding ...
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INTERNATIONAL CONFERENCE ON SCIENTIFIC RESEARCH & INNOVATION (ICSRI 2022)
The emanation of the "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)&q... more The emanation of the "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)" has resulted in the "coronavirus disease (COVID-19)" cosmopolitan widespread of the virus. First, the Iraqi government forced compulsory quarantine of returning travelers and positive cases to curb and manage the viral outbreak. A COVID-19 positive cases descriptive evaluation in a quarantine facility in Baghdad-Iraq was performed. The age and gender prevalence of positive cases distributed according to gender, age group, and mean age, recovered and deceased were recorded and analyzed statistically. Up to 434 positive cases, 196 males and 238 females with age range (≤ 20-≥ 70 years) were included. The highest infection was among the age group (60-69 years) in both genders recorded at 25.5% among males and 23.5% among females (P = 0.055). The total number of recovered patients was 347, the highest percentage recorded at 24.8% among the age group (40-49 years) meanwhile; 57 patients were deceased recorded at 28.1% among the age group (60-69 years) (P = 0.051). The highest COVID 19 recovered cases distributed according to gender were 53.0% among females. Meanwhile; the highest deceased patients were males recorded 54.4% (P = 0.299). The evaluation revealed an immense need to power the quarantine medical institution for managing the flood of confirmed COVID-19 patients among the elderly who suffered from chronic lung diseases complications including pneumonia and acute respiratory failure.
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PROCEEDINGS OF THE 1ST INTERNATIONAL CONFERENCE ON FRONTIER OF DIGITAL TECHNOLOGY TOWARDS A SUSTAINABLE SOCIETY
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International Journal of Current Research
ABSTRACT
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Meta Gene
Abstract Background Vitamin D receptor (VDR) genetic polymorphisms have been stated to be related... more Abstract Background Vitamin D receptor (VDR) genetic polymorphisms have been stated to be related with thalassemia, in addition to the environmental factors that enhanced the disease in genetically predisposed individuals. Also, it's responsible for bone metabolism regulation, as well its role in the immunity. Aim The present study designated to investigate the relationship between VDR genetic polymorphisms and thalassemia among Iraqi population and compared the present frequencies to other frequencies among Arabian population. Materials and methods Apa-I and Taq-I restriction enzymes were used to investigate VDR single nucleotide polymorphisms (SNPs) frequency by polymerase chain reaction – Restriction fragment length polymorphisms (RFLP) of the targeted segments (rs7975232 and rs731236) in 70 Iraqi patients with thalassemia and 75 Iraqi healthy volunteers as control group. In addition, a comparison was done between the present findings for the healthy volunteers and other previous findings among the healthy Arabian populations. Results A novel study of VDR rs7975232 and rs731236 genotyping and allele frequencies were demonstrated among the Iraqi thalassemic patients and the Arabian thalassemic patients. The present findings revealed a significant difference of VDR polymorphisms rs7975232 and rs731236 in thalassemia patient's group compared to healthy controls. In rs7975232, AA genotype was significantly increased in thalassemia patients' group compared to controls (54.29 vs. 9.33%, OR: 11.54, p: 9.1 × 10−9). Also, A allele frequency was significantly increased in thalassemia patients' group compared to controls (71 vs. 25%, OR: 7.34, p: 9.0 × 10−11). In contrast, the results of VDR polymorphisms rs731236 were appeared the CC genotyping frequency was significantly increased in thalassemia patient's group compared to controls (50.0 vs. 6.67%, OR: 14.0, p: 5.8 × 10−9). Also, C allele showed a significant increased frequency in thalassemia patient's group compared to controls (71.0 vs. 19.0, OR: 10.44, p: 1.0 × 10−13). Also, it demonstrates the variation of VDR polymorphisms rs7975232 and rs731236 between the Iraqi healthy controls and other healthy controls in the Arabian population. Conclusion The present findings showed a significant association between VDR polymorphisms and thalassemia in Iraqi patients, the AA genotype and A allele frequencies were significantly increased in thalassemia patients' group compared to controls in VDR polymorphism rs7975232. While, the CC genotype and C allele frequencies were significantly increased in thalassemia patients' group compared to controls in VDR polymorphism rs731236. Also, it demonstrates the variation of VDR polymorphisms between the Iraqi healthy controls and other healthy controls in the Arabian population.
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3RD INTERNATIONAL SCIENTIFIC CONFERENCE OF ALKAFEEL UNIVERSITY (ISCKU 2021), 2022
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Baghdad Science Journal, 2020
Fumonisin B1 (FB1) is a mycotoxin produced in some grains (mainly corn) by Fusarium species. Due ... more Fumonisin B1 (FB1) is a mycotoxin produced in some grains (mainly corn) by Fusarium species. Due to a structural similarity between FB1 and sphinganine, sphingolipids metabolism is inhibited. Such inhibition plays a critical role in cell to cell singling and structure of lipoprotein; therefore FB1 has been suggested to have a relationship with human and animal cancer. This research is planned to study the effect of FB1 on male mice at two doses (20 and 30 µg/ ml) on the expression of TGF-β1 and p16 in liver cells. Three groups of Swiss albino male mice; each group was orally administrated with FB1 toxin as the following: normal saline (control group); 20 and 30 µg/ ml. All groups were sacrificed after two weeks of oral management. Liver samples were collected and prepared for immunohistochemistry technique (IHC) using anti-TGF-β1 and anti-p16 antibodies. The results showed that exposure to FB1 caused significant elevation of TGF-β1 in both doses (76.74 ± 2.387% and 80.62 ± 7.277%, r...
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Pseudomonas fluorescens isolate was isolated from soil. The antibacterial activity of crude extra... more Pseudomonas fluorescens isolate was isolated from soil. The antibacterial activity of crude extract of this isolate was determined against pathogenic bacteria (Klebsiella pneumonia, Staphylococcus aureus) which are isolated from patients with skin infections. The extraction of this substance was done and study it characterization after purified by silica gel chromatography, It was stable within range of pH (5-9) at 37 oC for 24 hr. and inactivated by serum at concentration > 50%. The substance was soluble in methylene chloride, chloroform, acetone, sodium hydroxide and hydrochloric acid and it was insoluble in water, methanol, ethyl acetate and hexane.
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Meta Gene, 2020
Abstract Background Vitamin D receptor (VDR) genetic polymorphisms have been stated to be related... more Abstract Background Vitamin D receptor (VDR) genetic polymorphisms have been stated to be related with thalassemia, in addition to the environmental factors that enhanced the disease in genetically predisposed individuals. Also, it's responsible for bone metabolism regulation, as well its role in the immunity. Aim The present study designated to investigate the relationship between VDR genetic polymorphisms and thalassemia among Iraqi population and compared the present frequencies to other frequencies among Arabian population. Materials and methods Apa-I and Taq-I restriction enzymes were used to investigate VDR single nucleotide polymorphisms (SNPs) frequency by polymerase chain reaction – Restriction fragment length polymorphisms (RFLP) of the targeted segments (rs7975232 and rs731236) in 70 Iraqi patients with thalassemia and 75 Iraqi healthy volunteers as control group. In addition, a comparison was done between the present findings for the healthy volunteers and other previous findings among the healthy Arabian populations. Results A novel study of VDR rs7975232 and rs731236 genotyping and allele frequencies were demonstrated among the Iraqi thalassemic patients and the Arabian thalassemic patients. The present findings revealed a significant difference of VDR polymorphisms rs7975232 and rs731236 in thalassemia patient's group compared to healthy controls. In rs7975232, AA genotype was significantly increased in thalassemia patients' group compared to controls (54.29 vs. 9.33%, OR: 11.54, p: 9.1 × 10−9). Also, A allele frequency was significantly increased in thalassemia patients' group compared to controls (71 vs. 25%, OR: 7.34, p: 9.0 × 10−11). In contrast, the results of VDR polymorphisms rs731236 were appeared the CC genotyping frequency was significantly increased in thalassemia patient's group compared to controls (50.0 vs. 6.67%, OR: 14.0, p: 5.8 × 10−9). Also, C allele showed a significant increased frequency in thalassemia patient's group compared to controls (71.0 vs. 19.0, OR: 10.44, p: 1.0 × 10−13). Also, it demonstrates the variation of VDR polymorphisms rs7975232 and rs731236 between the Iraqi healthy controls and other healthy controls in the Arabian population. Conclusion The present findings showed a significant association between VDR polymorphisms and thalassemia in Iraqi patients, the AA genotype and A allele frequencies were significantly increased in thalassemia patients' group compared to controls in VDR polymorphism rs7975232. While, the CC genotype and C allele frequencies were significantly increased in thalassemia patients' group compared to controls in VDR polymorphism rs731236. Also, it demonstrates the variation of VDR polymorphisms between the Iraqi healthy controls and other healthy controls in the Arabian population.
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Journal of Al-Nahrain University Science, 2009
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ABSTRACT
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Papers by Sinai W . Mohammed