▪ Abstract Perhaps in keeping with their enigmatic name, 14-3-3 proteins offer a seemingly
bewildering array of opportunities for interaction with signal transduction pathways. In each …

The 14-3-3 proteins are small, cytosolic, evolutionaritly conserved proteins expressed
abundantly in the nervous system. Although they were discovered more than 30 yr ago, their …

One hallmark of signal transduction events is the phosphorylation-induced transition of a
protein from one activity state to another. Kinases, phosphatases, transcription factors, and …

14-3-3 proteins were originally discovered as a family of proteins that are highly expressed
in the brain. Through interactions with a multitude of binding partners, 14-3-3 proteins impact …

Members of the highly conserved and ubiquitous 14-3-3 protein family modulate a wide
variety of cellular processes. To determine the evolutionary relationships among specific 14-3-3 …

The localisation of 14-3-3 proteins compared to that of tau and ubiquitin-protein conjugates
in sections of hippocampus from Alzheimer's disease (AD) brains was examined by …

14-3-3 protein:; and tissue damage association were determined. The localization of 14-3-3
proteins in section of cortex from ischemia produced rats was examined by …

14-3-3s are a group of relatively low molecular weight, acidic, dimeric, protein(s) conserved
from single-celled yeast to multicellular vertebrates including humans. Despite lacking …

Background: The kinase Tor is the target of the immunosuppressive drug rapamycin and is
a member of the phosphatidylinositol kinase (PIK)-related kinase family. It plays an essential …

The site of (se&e) is in a Ser-Pro-&-L such as a cyclindependent kinase, may be responsible.
Since the Msoform interacts more strongly w”; th PKC than does the r;-isoforr@, could this …