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Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus.

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Affiliations

  • 1. Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Japan.
      Authors
    • Okumura A 1
    (1 author)

Journal of Virology, 01 Jun 1996, 70(6):4146-4149
https://doi.org/10.1128/jvi.70.6.4146-4149.1996 PMID: 8648758 PMCID: PMC190306

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Abstract 

A persistently coronavirus-infected embryonic stem (ES) cell line A3/MHV was established by infecting an ES cell line, A3-1, with mouse hepatitis virus type-2. Although almost all A3/MHV cells were found infected, both A3/MHV and A3-1 cells expressed comparable levels of cell surface differentiation markers. In addition, A3/MHV cells retained the ability to form embryoid bodies. These results suggest that persistent coronavirus infection does not affect the differentiation of ES cells.

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J Virol. 1996 Jun; 70(6): 4146–4149.
PMCID: PMC190306
PMID: 8648758

Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus.

A Okumura, K Machii, S Azuma, Y Toyoda, and S Kyuwa
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Abstract

A persistently coronavirus-infected embryonic stem (ES) cell line A3/MHV was established by infecting an ES cell line, A3-1, with mouse hepatitis virus type-2. Although almost all A3/MHV cells were found infected, both A3/MHV and A3-1 cells expressed comparable levels of cell surface differentiation markers. In addition, A3/MHV cells retained the ability to form embryoid bodies. These results suggest that persistent coronavirus infection does not affect the differentiation of ES cells.

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Selected References
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