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Determination of the gene sequence of poliovirus with pactamycin.

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Affiliations

  • 1. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461
      Authors
    • Summers DF 1
    • Maizel JV Jr 1
    (2 authors)

Proceedings of the National Academy of Sciences of the United States of America, 01 Nov 1971, 68(11):2852-2856
https://doi.org/10.1073/pnas.68.11.2852 PMID: 4330946 PMCID: PMC389541

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Abstract 

By examination of the virus-specific polypeptides formed after the addition of pactamycin, an inhibitor of protein chain initiation, to infected cells, it has been possible to tentatively locate the virus coat proteins at the amino terminus of the large, virus-specific protein precursor, and, therefore, to assign the coat protein cistron to the 5' end of the RNA.

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Proc Natl Acad Sci U S A. 1971 Nov; 68(11): 2852–2856.
PMCID: PMC389541
PMID: 4330946

Determination of the Gene Sequence of Poliovirus with Pactamycin

D. F. Summers*† and J. V. Maizel, Jr.*
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Abstract

By examination of the virus-specific polypeptides formed after the addition of pactamycin, an inhibitor of protein chain initiation, to infected cells, it has been possible to tentatively locate the virus coat proteins at the amino terminus of the large, virus-specific protein precursor, and, therefore, to assign the coat protein cistron to the 5′ end of the RNA.

Full text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • PENMAN S, BECKER Y, DARNELL JE. A CYTOPLASMIC STRUCTURE INVOLVED IN THE SYNTHESIS AND ASSEMBLY OF POLIOVIRUS COMPONENTS. J Mol Biol. 1964 Apr;8:541–555. [Abstract] [Google Scholar]
  • Summers DF, Levintow L. Constitution and function of polyribosomes of poliovirus-infected HeLa cells. Virology. 1965 Sep;27(1):44–53. [Abstract] [Google Scholar]
  • Summers DF, Maizel JV., Jr Evidence for large precursor proteins in poliovirus synthesis. Proc Natl Acad Sci U S A. 1968 Mar;59(3):966–971. [Europe PMC free article] [Abstract] [Google Scholar]
  • Holland JJ, Kiehn ED. Specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses. Proc Natl Acad Sci U S A. 1968 Jul;60(3):1015–1022. [Europe PMC free article] [Abstract] [Google Scholar]
  • Jacobson MF, Baltimore D. Polypeptide cleavages in the formation of poliovirus proteins. Proc Natl Acad Sci U S A. 1968 Sep;61(1):77–84. [Europe PMC free article] [Abstract] [Google Scholar]
  • Jacobson MF, Asso J, Baltimore D. Further evidence on the formation of poliovirus proteins. J Mol Biol. 1970 May 14;49(3):657–669. [Abstract] [Google Scholar]
  • Roumiantzeff M, Summers DF, Maizel JV., Jr In vitro protein synthetic activity of membrane-bound poliovirus polyribosomes. Virology. 1971 May;44(2):249–258. [Abstract] [Google Scholar]
  • Macdonald JS, Goldberg IH. An effect of pactamycin on the initiation of protein synthesis in reticulocytes. Biochem Biophys Res Commun. 1970 Oct 9;41(1):1–8. [Abstract] [Google Scholar]
  • Summers DF, Maizel JV, Jr, Darnell JE., Jr Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A. 1965 Aug;54(2):505–513. [Europe PMC free article] [Abstract] [Google Scholar]
  • Cooper PD, Summers DF, Maizel JV. Evidence for ambiguity in the posttranslational cleavage of poliovirus proteins. Virology. 1970 Jul;41(3):408–418. [Abstract] [Google Scholar]
  • Mudd JA, Summers DF. Polysomal ribonucleic acid of vesicular stomatitis virus-infected HeLa cells. Virology. 1970 Dec;42(4):958–968. [Abstract] [Google Scholar]
  • Gaskill P, Kabat D. Unexpectedly large size of globin messenger ribonucleic acid. Proc Natl Acad Sci U S A. 1971 Jan;68(1):72–75. [Europe PMC free article] [Abstract] [Google Scholar]
  • Granboulan N, Girard M. Molecular weight of poliovirus ribonucleic acid. J Virol. 1969 Oct;4(4):475–479. [Europe PMC free article] [Abstract] [Google Scholar]
Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

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