Europe PMC
Nothing Special   »   [go: up one dir, main page]

Europe PMC requires Javascript to function effectively.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page.

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection.

Show less

Author information

Affiliations

  • 1. Institute of Immunology, Third Military Medical University, Chongqing 400038, China.
      Authors
    • He R 1
    • Liu C 1
    • Bai Q 1
    • Yang X 1
    • Xu L 1
    • Chen X 1
    • Hao Y 1
    • Wang P 1
    • Zhou X 1
    • Wu Y 1
    • Ye L 1
    (11 authors)
  • 2. Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University, Beijing 100084, China.
      Authors
    • Hou S 2
    • Qi H 2
    (2 authors)
  • 3. Shanghai Public Health Clinical Center &Institutes of Biomedical Sciences, Fudan University, Shanghai 201508, China.
      Authors
    • Zhang A 3
    • Yang Y 3
    • Zhang X 3
    • Xu J 3
    (4 authors)
  • 4. State Key Laboratory of Genetic Engineering &MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
      Authors
    • Han M 4
    • Wei G 4
    • Shen T 4
    • Ni T 4
    (4 authors)
  • 5. Department of Anatomy, School of Basic Medicine, Third Military Medical University, Chongqing 400038, China.
      Authors
    • Zhu C 5
    (1 author)
    • Show all (8)

ORCIDs linked to this article

Show all (7)

Nature, 01 Aug 2016, 537(7620):412-428
https://doi.org/10.1038/nature19317 PMID: 27501245 

This article has been corrected. See Nature. 2016 Oct 19;540(7633):470. A comment on this article appears in "Immunology: Cytotoxic T cells that escape exhaustion." Nature. 2016 Sep 15;537(7620):312-314.

Abstract 

During chronic viral infection, virus-specific CD8(+) T cells become exhausted, exhibit poor effector function and lose memory potential. However, exhausted CD8(+) T cells can still contain viral replication in chronic infections, although the mechanism of this containment is largely unknown. Here we show that a subset of exhausted CD8(+) T cells expressing the chemokine receptor CXCR5 has a critical role in the control of viral replication in mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV). These CXCR5(+) CD8(+) T cells were able to migrate into B-cell follicles, expressed lower levels of inhibitory receptors and exhibited more potent cytotoxicity than the CXCR5(-) [corrected] subset. Furthermore, we identified the Id2-E2A signalling axis as an important regulator of the generation of this subset. In patients with HIV, we also identified a virus-specific CXCR5(+) CD8(+) T-cell subset, and its number was inversely correlated with viral load. The CXCR5(+) subset showed greater therapeutic potential than the CXCR5(-) [corrected] subset when adoptively transferred to chronically infected mice, and exhibited synergistic reduction of viral load when combined with anti-PD-L1 treatment. This study defines a unique subset of exhausted CD8(+) T cells that has a pivotal role in the control of viral replication during chronic viral infection.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/nature19317

References 

Articles referenced by this article (37)

Show 10 more references (10 of 37)

Citations & impact 

Impact metrics

400
Citations
Jump to Citations
13
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/10213158
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/10213158

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1038/nature19317

Supporting
Mentioning
Contrasting
47
663
4

Article citations

Go to all (400) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.