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Follicular stromal cells and lymphocyte homing to follicles.

Author information

Affiliations

  • 1. Department of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA.
      Authors
    • Cyster JG 1
    (1 author)

ORCIDs linked to this article

Immunological Reviews, 01 Aug 2000, 176:181-193
https://doi.org/10.1034/j.1600-065x.2000.00618.x PMID: 11043777 

Review

Abstract 

Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.

Full text links 

Read article at publisher's site: https://doi.org/10.1034/j.1600-065x.2000.00618.x

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Funding 

Funders who supported this work.

NIAID NIH HHS (2)