The 2001 Coca-Cola 600, the 42nd running of the event, was a NASCAR Winston Cup Series race held on May 27, 2001 at Lowe's Motor Speedway in Charlotte, North Carolina. Contested at 400 laps on the 1.5 mile (2.4 km) speedway, it was the twelfth race of the 2001 NASCAR Winston Cup Series season. Jeff Burton of Roush Racing won the race.