About: Rolapitant

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Rolapitant (INN, trade name Varubi /vəˈruːbi/ və-ROO-bee in the US and Varuby in the European Union) is a drug originally developed by Schering-Plough and licensed for clinical development by Tesaro, which acts as a selective NK1 receptor antagonist (antagonist for the NK1 receptor). It has been approved as a medication for the treatment of chemotherapy-induced nausea and vomiting (CINV) after clinical trials showed it to have similar or improved efficacy and some improvement in safety over existing drugs for this application.

Property	Value
dbo:abstract	Rolapitant (INN, trade name Varubi /vəˈruːbi/ və-ROO-bee in the US and Varuby in the European Union) is a drug originally developed by Schering-Plough and licensed for clinical development by Tesaro, which acts as a selective NK1 receptor antagonist (antagonist for the NK1 receptor). It has been approved as a medication for the treatment of chemotherapy-induced nausea and vomiting (CINV) after clinical trials showed it to have similar or improved efficacy and some improvement in safety over existing drugs for this application. (en)
dbo:alternativeName	Varubi (US), Varuby (EU) (en)
dbo:casNumber	552292-08-7
dbo:chEBI	90908
dbo:drugbank	DB09291
dbo:fdaUniiCode	NLE429IZUC
dbo:kegg	D08988 D10742
dbo:medlinePlus	a615041
dbo:pubchem	10311306
dbo:thumbnail	wiki-commons:Special:FilePath/Rolapitant_(Patent_Verified).svg?width=300
dbo:wikiPageExternalLink	https://druginfo.nlm.nih.gov/drugportal/name/rolapitant https://medlineplus.gov/druginfo/meds/a618019.html
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dbo:wikiPageWikiLink	dbc:Gamma-lactams dbr:Pyrrolidine dbr:Schering-Plough dbr:Blood_plasma dbr:Antiemetic dbr:Area_under_the_curve_(pharmacokinetics) dbc:NK1_receptor_antagonists dbr:Rifampicin dbr:Stomatitis dbc:GSK_plc_brands dbc:Spiro_compounds dbc:Trifluoromethyl_compounds dbr:Chemotherapy-induced_nausea_and_vomiting dbr:Oral_administration dbr:Tachykinin_receptor_2 dbr:Elimination_half-life dbr:Enzyme dbr:Thioridazine dbr:Clinical_trial dbr:Active_metabolite dbr:5-HT3_antagonist dbc:Antiemetics dbr:PH dbr:Palonosetron dbr:Receptor_(biochemistry) dbr:International_Nonproprietary_Name dbr:Tesaro dbr:Hydrochloride dbr:ABCG2 dbr:Chemotherapy dbr:Affinity_(pharmacology) dbr:Binding_selectivity dbr:Sulfasalazine dbr:Tablet_(pharmacy) dbr:Monohydrate dbr:Dexamethasone dbr:Dextromethorphan dbr:Digoxin dbr:CYP2D6 dbr:CYP3A4 dbr:Placebo dbr:St._John's_Wort dbr:Hygroscopic dbr:Neutropenia dbr:NK1_receptor_antagonist dbr:Intravenous dbr:Tachykinin_receptor_1 dbr:P-glycoprotein dbr:Enzyme_substrate dbr:First-pass_effect dbr:Plasma_protein dbr:Antagonist_(pharmacology) dbr:File:C4-pyrrolidine-hydroxylated_rolapitant.svg
dbp:atcPrefix	A04 (en)
dbp:atcSuffix	AD14 (en)
dbp:bioavailability	nearly 100% (en)
dbp:c	25 (xsd:integer)
dbp:casNumber	552292 (xsd:integer)
dbp:chebi	90908 (xsd:integer)
dbp:chemspiderid	8486772 (xsd:integer)
dbp:dailymedid	Rolapitant (en)
dbp:drugbank	DB09291 (en)
dbp:eliminationHalfLife	-658800.0
dbp:excretion	Feces , urine (en)
dbp:f	6 (xsd:integer)
dbp:h	26 (xsd:integer)
dbp:index2Label	as HCl (en)
dbp:iupacName	-8 (xsd:integer)
dbp:iupharLigand	5749 (xsd:integer)
dbp:kegg	D08988 (en) D10742 (en)
dbp:legalEu	Rx-only (en)
dbp:legalUs	Rx-only (en)
dbp:licenceEu	yes (en)
dbp:medlineplus	a615041 (en)
dbp:metabolism	dbr:CYP3A4
dbp:metabolites	C4-pyrrolidine-hydroxylated rolapitant (en)
dbp:n	2 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:pregnancyUs	N (en)
dbp:proteinBound	99.8
dbp:pubchem	10311306 (xsd:integer)
dbp:routesOfAdministration	By mouth , intravenous (en)
dbp:smiles	FCccccc4COCC3NCC1NCCC1 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	FIVSJYGQAIEMOC-ZGNKEGEESA-N (en)
dbp:synonyms	SCH 619734 (en)
dbp:tradename	Varubi , Varuby (en)
dbp:unii	NLE429IZUC (en)
dbp:width	225 (xsd:integer)
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dcterms:subject	dbc:Gamma-lactams dbc:NK1_receptor_antagonists dbc:GSK_plc_brands dbc:Spiro_compounds dbc:Trifluoromethyl_compounds dbc:Antiemetics
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Rolapitant (INN, trade name Varubi /vəˈruːbi/ və-ROO-bee in the US and Varuby in the European Union) is a drug originally developed by Schering-Plough and licensed for clinical development by Tesaro, which acts as a selective NK1 receptor antagonist (antagonist for the NK1 receptor). It has been approved as a medication for the treatment of chemotherapy-induced nausea and vomiting (CINV) after clinical trials showed it to have similar or improved efficacy and some improvement in safety over existing drugs for this application. (en)
rdfs:label	Rolapitant (en)
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prov:wasDerivedFrom	wikipedia-en:Rolapitant?oldid=1102283741&ns=0
foaf:depiction	wiki-commons:Special:FilePath/C4-pyrrolidine-hydroxylated_rolapitant.svg wiki-commons:Special:FilePath/Rolapitant_(Patent_Verified).svg
foaf:isPrimaryTopicOf	wikipedia-en:Rolapitant
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is dbo:wikiPageWikiLink of	dbr:Antiemetic dbr:Postoperative_nausea_and_vomiting dbr:Chemotherapy-induced_nausea_and_vomiting dbr:Tesaro dbr:ATC_code_A04 dbr:NK1_receptor_antagonist dbr:List_of_drugs:_Rf–Rz dbr:Rolapitant_hydrochloride dbr:Varubi dbr:Varuby
is foaf:primaryTopic of	wikipedia-en:Rolapitant