About: Edotreotide

Property	Value
dbo:abstract	Edotreotid ist der Internationale Freiname für den Arzneistoff (DOTA(0)-Phe(1)-Tyr(3))octreotid. In der Fachwelt ist die Bezeichnung DOTATOC am gebräuchlichsten. Edotreotid wird zusammen mit verschiedenen Radionukliden als Radiopharmakon in der Onkologie sowohl zur Diagnostik als auch zur Therapie (Radionuklidtherapie) verwendet. Die (RPT) mit 90Y-DOTATOC wird insbesondere bei fortgeschrittenen neuroendokrinen Tumoren (NET) als palliatives Behandlungsverfahren eingesetzt und klinisch getestet. (de) Edotreotide (USAN, also known as (DOTA0-Phe1-Tyr3) octreotide, DOTA-TOC, DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer. When used therapeutically it is an example of peptide receptor radionuclide therapy. (en) エドトレオチド（Edotreotide、DOTATOC、開発コードSMT487）は（DOTA0-Phe1-Tyr3）オクトレオチドとも呼ばれるキレート剤の一つである。様々な放射性同位体を担持させ、ある種の癌の診断・治療に用いられる。若年者（25歳以下）の悪性腫瘍を、正常細胞を傷付ける事なく発見できる方法として、米国NCIが研究中である。研究対象には神経芽細胞腫、小児脳腫瘍、が含まれる。進行神経内分泌腫瘍（NET）の姑息的治療に90Y-DOTATOCを用いる研究が実施されている。 (ja)
dbo:iupacName	2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(2R,3R)-1,3-dihydroxybutan-2-yl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid (en)
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dbp:drugbank	DB15494 (en)
dbp:imagefile	Edotreotide.svg (en)
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dbp:iupacname	2 (xsd:integer)
dbp:tradename	SomaKit TOC (en)
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dct:subject	dbc:Macrocycles dbc:DOTA_(chelator)_derivatives dbc:Radiopharmaceuticals dbc:Multiple_Chemboxes dbc:Nuclear_medicine_procedures dbc:Somatostatin_receptor_agonists dbc:Cyclic_peptides
gold:hypernym	dbr:Substance
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rdfs:comment	Edotreotid ist der Internationale Freiname für den Arzneistoff (DOTA(0)-Phe(1)-Tyr(3))octreotid. In der Fachwelt ist die Bezeichnung DOTATOC am gebräuchlichsten. Edotreotid wird zusammen mit verschiedenen Radionukliden als Radiopharmakon in der Onkologie sowohl zur Diagnostik als auch zur Therapie (Radionuklidtherapie) verwendet. Die (RPT) mit 90Y-DOTATOC wird insbesondere bei fortgeschrittenen neuroendokrinen Tumoren (NET) als palliatives Behandlungsverfahren eingesetzt und klinisch getestet. (de) Edotreotide (USAN, also known as (DOTA0-Phe1-Tyr3) octreotide, DOTA-TOC, DOTATOC) is a substance which, when bound to various radionuclides, is used in the treatment and diagnosis of certain types of cancer. When used therapeutically it is an example of peptide receptor radionuclide therapy. (en) エドトレオチド（Edotreotide、DOTATOC、開発コードSMT487）は（DOTA0-Phe1-Tyr3）オクトレオチドとも呼ばれるキレート剤の一つである。様々な放射性同位体を担持させ、ある種の癌の診断・治療に用いられる。若年者（25歳以下）の悪性腫瘍を、正常細胞を傷付ける事なく発見できる方法として、米国NCIが研究中である。研究対象には神経芽細胞腫、小児脳腫瘍、が含まれる。進行神経内分泌腫瘍（NET）の姑息的治療に90Y-DOTATOCを用いる研究が実施されている。 (ja)
rdfs:label	Edotreotid (de) Edotreotide (en) エドトレオチド (ja)
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