The Guyandotte River Crayfish (Cambarus veteranus) is a species of crayfish found in a small stream system in Wyoming County, West Virginia, USA. They are closely related to the Big Sandy crayfish, and until recently, the two were thought to belong to the same species. The Guyandotte River Crayfish is currently listed as Data Deficient by the IUCN and was listed under the Endangered Species Act with the Big Sandy Crayfish on April 4th, 2016.