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About: Cache domain

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibr

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dbo:abstract
  • In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source. The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions. (en)
dbo:symbol
  • Cache_1
  • Cache_2
dbo:wikiPageID
  • 32179176 (xsd:integer)
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  • 2875 (xsd:nonNegativeInteger)
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  • 993699315 (xsd:integer)
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  • crystal structure of mcp_n and cache domains of methyl-accepting chemotaxis protein from vibrio cholerae (en)
  • crystal structure of methyl-accepting chemotaxis protein from vibrio parahaemolyticus rimd 2210633 (en)
dbp:interpro
  • IPR004010 (en)
  • IPR013163 (en)
dbp:name
  • Cache domain (en)
dbp:pfam
  • PF02743 (en)
  • PF08269 (en)
dbp:pfamClan
  • CL0165 (en)
dbp:symbol
  • Cache_1 (en)
  • Cache_2 (en)
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  • In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibr (en)
rdfs:label
  • Cache domain (en)
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