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Resonant laser ionization and mass separation of $^{225}$Ac
/ Johnson, Jake D (Leuven U.) ; Heines, Michael (Leuven U.) ; Bruchertseifer, Frank (Geel, JRC) ; Chevallay, Eric (CERN) ; Cocolios, Thomas E (Leuven U.) ; Dockx, Kristof (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heinitz, Stephan (SCK-CEN, Mol) ; Heinke, Reinhard (Leuven U. ; CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) et al.
$^{225}$Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $^{225}$Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $^{225}$Ac itself. [...]
2023 - 11 p.
- Published in : Sci. Rep. 13 (2023) 1347
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Towards reliable production of 225Ac for medical applications: Systematic analysis of the production of Fr, Ra and Ac beams.
/ Dockx, Kristof (KU Leuven, Belgium) ; Bruchertseifer, Frank (JRC-ITU, Germany) ; Cocolios, Thomas Elias (KU Leuven, Belgium) ; Dierckx, Marc (SCK-CEN, Belgium) ; Fedosseev, Valentin N (CERN, Switzerland) ; Fenwick, Andrew (NPL, United Kingdom) ; Giles, Tim (CERN, Switzerland) ; Houngbo, Donald (SCK-CEN, Belgium) ; Judge, Steven (NPL, United Kingdom) ; Keightley, John (NPL, United Kingdom) et al.
CERN-INTC-2017-016 ; INTC-P-498.
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2017.
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Production study of Fr, Ra and Ac radioactive ion beams at ISOLDE, CERN
/ Jajčišinová, E (Geel, JRC ; Leuven U.) ; Dockx, K (Leuven U.) ; Au, M (CERN) ; Bara, S (Leuven U.) ; Cocolios, T E (Leuven U.) ; Chrysalidis, K (CERN) ; Farooq‑Smith, G J (Leuven U. ; Edinburgh U.) ; Fedorov, D V (Unlisted) ; Fedosseev, V N (CERN) ; Flanagan, K T (Manchester U.) et al.
The presented paper discusses the production of radioactive ion beams of francium, radium, and actinium from thick uranium carbide (UC$_{x}$) targets at ISOLDE, CERN. This study focuses on the release curves and extractable yields of francium, radium and actinium isotopes. [...]
2024 - 9 p.
- Published in : Sci. Rep. 14 (2024) 11033
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Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS
/ Heinke, Reinhard (CERN ; Leuven U.) ; Chevallay, Eric (CERN) ; Chrysalidis, Katerina (CERN) ; Cocolios, Thomas E (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Fedosseev, Valentin N (CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) ; Lambert, Laura (CERN) ; Leenders, Benji (Leuven U. ; SCK-CEN, Mol ; Gent U.) ; Marsh, Bruce A (CERN) et al.
Thulium-167 is a promising radionuclide for nuclear medicine applications with potential use for both diagnosis and therapy (“theragnostics”) in disseminated tumor cells and small metastases, due to suitable gamma-line as well as conversion/Auger electron energies. However, adequate delivery methods are yet to be developed and accompanying radiobiological effects to be investigated, demanding the availability of $^{167}$Tm in appropriate activities and quality. [...]
2021
- Published in : Frontiers in Medicine 8 (2021) 712374
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Gamow-Teller decay population of Ni-64 levels in the decay of 1+ Co-64
/ Pauwels, D (SCK-CEN, Mol ; Leuven U.) ; Radulov, D (Leuven U.) ; Walters, W B (Maryland U., Dept. Chem.) ; Darby, I G (Leuven U.) ; De Witte, H (Leuven U.) ; Diriken, J (Leuven U.) ; Fedorov, D V (St. Petersburg, INP) ; Fedosseev, V N (CERN) ; Fraile, L M (Madrid U.) ; Huyse, M (Leuven U.) et al.
2012 - 6 p.
- Published in : Phys. Rev. C 86 (2012) 064318
APS published version, local copy: PDF;
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Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [$^{153}$Sm]Sm-DOTA-TATE
/ Vermeulen, Koen (SCK-CEN, Mol) ; Van de Voorde, Michiel (SCK-CEN, Mol) ; Segers, Charlotte (SCK-CEN, Mol) ; Coolkens, Amelie (SCK-CEN, Mol) ; Pérez, Sunay Rodriguez (SCK-CEN, Mol) ; Daems, Noami (SCK-CEN, Mol) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Crabbé, Melissa (SCK-CEN, Mol) ; Opsomer, Tomas (SCK-CEN, Mol) ; Vargas, Clarita Saldarriaga (SCK-CEN, Mol) et al.
Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of $^{152}$Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-Am $^{153}$Sm. [...]
2022 - 15 p.
- Published in : Pharmaceutics 14 (2022) 2566
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$\beta$-delayed fission and $\alpha$ decay of $^{196}$At
/ Truesdale, V L (York U., England) ; Andreyev, A N (York U., England ; JAEA, Ibaraki ; West Scotland U.) ; Ghys, L (Leuven U. ; SCK-CEN, Mol) ; Huyse, M (Leuven U.) ; Van Duppen, P (Leuven U.) ; Sels, S (Leuven U.) ; Andel, B (Comenius U.) ; Antalic, S (Comenius U.) ; Barzakh, A (St. Petersburg, INP) ; Capponi, L (West Scotland U.) et al.
A nuclear-decay spectroscopy study of the neutron-deficient isotope At196 is reported where an isotopically pure beam was produced using the selective Resonance Ionization Laser Ion Source and On-Line Isotope Mass Separator (CERN). The fine-structure α decay of At196 allowed the low-energy excited states in the daughter nucleus Bi192 to be investigated. [...]
2016 - 11 p.
- Published in : Phys. Rev. C 94 (2016) 034308
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Detailed $\alpha$-decay study of $^{180}\mathrm{Tl}$
/ Andel, B (Comenius U.) ; Andreyev, A N (York U., England ; JAEA, Ibaraki ; CERN) ; Antalic, S (Comenius U.) ; Barzakh, A (St. Petersburg, INP) ; Bree, N (Leuven U.) ; Cocolios, T E (Leuven U. ; CERN) ; Comas, V F (Darmstadt, GSI) ; Diriken, J (Leuven U.) ; Elseviers, J (Leuven U.) ; Fedorov, D V (St. Petersburg, INP) et al.
A detailed $\alpha$-decay spectroscopy study of $^{180}\mathrm{Tl}$ has been performed at ISOLDE (CERN). $Z$-selective ionization by the Resonance Ionization Laser Ion Source (RILIS) coupled to mass separation provided a high-purity beam of $^{180}\mathrm{Tl}$. [...]
2017 - 11 p.
- Published in : Phys. Rev. C 96 (2017) 054327
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SoLid: A short baseline reactor neutrino experiment
/ SoLid Collaboration
The SoLid experiment, short for Search for Oscillations with a Lithium-6 detector, is a new generation neutrino experiment which tries to address the key challenges for high precision reactor neutrino measurements at very short distances from a reactor core and with little or no overburden. The primary goal of the SoLid experiment is to perform a precise measurement of the electron antineutrino energy spectrum and flux and to search for very short distance neutrino oscillations as a probe of eV-scale sterile neutrinos. [...]
arXiv:2002.05914.-
2021-02-22 - 39 p.
- Published in : JINST 16 (2021) P02025
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