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First laser ions at the CERN-MEDICIS facility
/ MEDICIS Collaboration
The CERN-MEDICIS facility aims to produce emerging medical radionuclides for the theranostics approach in nuclear medicine with mass separation of ion beams. To enhance the radioisotope yield and purity of collected samples, the resonance ionization laser ion source MELISSA was constructed, and provided the first laser ions at the facility in 2019. [...]
2020 - 9 p.
- Published in : Hyperfine Interact. 241 (2020) 55
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Measurement of the laser resonance ionization efficiency for lutetium
/ Gadelshin, Vadim Maratovich (Mainz U. ; Ekaterinburg, Inst. Metal Phys.) ; Heinke, Reinhard (Mainz U., Inst. Phys.) ; Kieck, Tom (Mainz U., Inst. Phys.) ; Kron, Tobias (Mainz U., Inst. Phys.) ; Naubereit, Pascal (Mainz U., Inst. Phys.) ; Rösch, Frank (Mainz U., Inst. Phys.) ; Stora, Thierry (CERN) ; Studer, Dominik (Mainz U., Inst. Phys.) ; Wendt, Klaus (Mainz U., Inst. Phys.)
The development of a highly efficient resonance ionization scheme for lutetium is presented. A laser ion source, based on the all-solid-state Titanium:sapphire laser system, was used at the 30 keV RISIKO off-line mass separator to characterize different possible optical excitation schemes in respect to their ionization efficiency. [...]
2019 - 9 p.
- Published in : Radiochim. Acta 107 (2019) 653-661
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3.
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Laser resonance ionization spectroscopy on lutetium for the MEDICIS project
/ Gadelshin, V (Mainz U., Inst. Phys. ; Urals State U.) ; Cocolios, T (Leuven U.) ; Fedoseev, V (CERN) ; Heinke, R (Mainz U., Inst. Phys.) ; Kieck, T (Mainz U., Inst. Phys.) ; Marsh, B (CERN) ; Naubereit, P (Mainz U., Inst. Phys.) ; Rothe, S (CERN ; U. Manchester (main)) ; Stora, T (CERN) ; Studer, D (Mainz U., Inst. Phys.) et al.
The MEDICIS-PROMED Innovative Training Network under the Horizon 2020 EU program aims to establish a network of early stage researchers, involving scientific exchange and active cooperation between leading European research institutions, universities, hospitals, and industry. Primary scientific goal is the purpose of providing and testing novel radioisotopes for nuclear medical imaging and radionuclide therapy. [...]
2017 - 7 p.
- Published in : Hyperfine Interact. 238 (2017) 28
Preprint: PDF;
In : 10th International Workshop on Application of Lasers and Storage Devices in Atomic Nuclei Research : Recent Achievements and Future Prospects, Poznan, Poland, 16 - 19 May 2016, pp.28
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4.
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Very high specific activity erbium $^{169}$Er production for potential receptor-targeted radiotherapy
/ Formento-Cavaier, R (ADACAP,Saint-Genis-Pouilly ; GIP ARRONAX ; SUBATECH, Nantes) ; Köster, U (Laue-Langevin Inst.) ; Crepieux, B (CERN) ; Gadelshin, V M (Mainz U., Inst. Phys. ; Urals State U.) ; Haddad, F (GIP ARRONAX ; SUBATECH, Nantes) ; Stora, T (CERN) ; Wendt, K (Mainz U., Inst. Phys.)
Erbium $^{169}$Er is one of the most interesting radiolanthanides for new potential receptor-targeted β − therapy applications due to its low energy β − emissions, very low intensity ɣ rays and the possibility to use 68 Ga or 44 Sc as companion for diagnostic in a theranostics approach. Currently it can be produced in reactors through the neutron activation of highly enriched $^{168}$Er. [...]
2020 - 4 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 463 (2020) 468-471
In : 18th International Conference on Electromagnetic Isotope Separators and Related Topics, Geneva, Switzerland, 16 - 21 Sep 2018, pp.468-471
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5.
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Target Development towards First Production of High-Molar- Activity $^{44g}$Sc and $^{47}$Sc by Mass Separation at CERN-MEDICIS
/ Mamis, Edgars (CERN ; Latvia U.) ; Duchemin, Charlotte (CERN) ; Berlin, Valentina (CERN) ; Bernerd, Cyril (CERN) ; Bovigny, Mathieu (CERN) ; Chevallay, Eric (CERN) ; Crepieux, Bernard (CERN) ; Gadelshin, Vadim Maratovich (Mainz U., Inst. Phys.) ; Heinke, Reinhard (CERN) ; Hernandez, Ronaldo Mendez (CERN ; Havana, ISCTN) et al.
The radionuclides 43Sc, 44g/mSc, and 47Sc can be produced cost-effectively in sufficient yield for medical research and applications by irradiating natTi and natV target materials with protons. Maximizing the production yield of the therapeutic 47Sc in the highest cross section energy range of 24–70 MeV results in the co-production of long-lived, high-γ-ray-energy 46Sc and 48Sc contaminants if one does not use enriched target materials. [...]
2024 - 28 p.
- Published in : Pharmaceuticals 17 (2024) 390
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CERN-MEDICIS: A Review Since Commissioning in 2017
/ MEDICIS Collaboration
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. [...]
2021 - 11 p.
- Published in : Frontiers in Medicine 8 (2021) 693682
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Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL
/ Raeder, S (KU Leuven, Dept. Phys. Astron.) ; Bastin, B (GANIL) ; Block, M (Helmholtz-Institut Mainz) ; Creemers, P (KU Leuven, Dept. Phys. Astron.) ; Delahaye, P (GANIL) ; Ferrer, R (KU Leuven, Dept. Phys. Astron.) ; Fléchard, X (Caen U.) ; Franchoo, S (Orsay, IPN) ; Ghys, L (KU Leuven, Dept. Phys. Astron.) ; Gaffney, L P (KU Leuven, Dept. Phys. Astron.) et al.
To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. [...]
2016 - 6 p.
- Published in : Nucl. Instrum. Methods Phys. Res., B 376 (2016) 382-387
In : 17th International Conference on Electromagnetic Isotope Separators and Related Topics, Grand Rapids, USA, 11 - 15 May 2015, pp.382-387
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8.
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Towards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion
/ Ferrer, R (KU Leuven, Dept. Phys. Astron.) ; Barzakh, A (St. Petersburg, INP) ; Bastin, B (GANIL) ; Beerwerth, R (Helmholtz Inst., Jena ; Jena U., TPI) ; Block, M (Darmstadt, GSI ; Helmholtz Inst., Mainz ; Mainz U., Inst. Kernchem.) ; Creemers, P (KU Leuven, Dept. Phys. Astron.) ; Grawe, H (Darmstadt, GSI) ; de Groote, R (KU Leuven, Dept. Phys. Astron.) ; Delahaye, P (GANIL) ; Fléchard, X (Caen U.) et al.
Resonant laser ionization and spectroscopy are widely used techniques at radioactive ion
beam facilities to produce pure beams of exotic nuclei and measure the shape, size, spin and
electromagnetic multipole moments of these nuclei. However, in such measurements it is
difficult to combine a high efficiency with a high spectral resolution. [...]
2017 - 9 p.
- Published in : Nature Commun. 8 (2017) 14520
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The electron affinity of astatine
/ Leimbach, David (CERN ; U. Gothenburg (main) ; Mainz U., Inst. Phys.) ; Karls, Julia (U. Gothenburg (main)) ; Guo, Yangyang (U. Groningen, VSI) ; Ahmed, Rizwan (NCP, Islamabad) ; Ballof, Jochen (CERN ; Mainz U., Inst. Kernchem.) ; Bengtsson, Lars (U. Gothenburg (main)) ; Pamies, Ferran Boix (CERN) ; Borschevsky, Anastasia (U. Groningen, VSI) ; Chrysalidis, Katerina (CERN ; Mainz U., Inst. Phys.) ; Eliav, Ephraim (Tel Aviv U. (main)) et al.
One of the most important properties influencing the chemical behavior of an element is the electron affinity (EA). Among the remaining elements with unknown EA is astatine, where one of its isotopes, $^{211}$At, is remarkably well suited for targeted radionuclide therapy of cancer. [...]
arXiv:2002.11418.-
2020 - 9 p.
- Published in : Nature Commun. 11 (2020) 3824
Fulltext: PDF; Fulltext from publisher: PDF;
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