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1.
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Measurement of $^{12}$C Fragmentation Cross Sections on C, O, and H in the Energy Range of Interest for Particle Therapy Applications
/ Mattei, I ; Alexandrov, A ; Alunni Solestizi, L ; Ambrosi, G ; Argiro, S ; Bartosik, N ; Battistoni, G ; Belcari, N ; Biondi, S ; Bisogni, M G et al.
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumor and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. [...]
2020 - 14 p.
- Published in : IEEE Trans. Rad. Plasma Med. Sci. 4 (2020) 269-282
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2.
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Ion charge separation with new generation of nuclear emulsion films
/ Montesi, M.C. (Naples U. ; INFN, Naples) ; Lauria, A. (Naples U. ; INFN, Naples) ; Alexandrov, A. (INFN, Naples ; Naples U. ; Natl. U. Sci. Tech., Moscow ; Lebedev Inst.) ; Solestizi, L. Alunni (INFN, Perugia ; Perugia U.) ; Giovanni, Ambrosi (INFN, Perugia) ; Argirò, S. (Turin U. ; INFN, Turin) ; Diaz, R. (Havana, CEADEN) ; Bartosik, N. (INFN, Turin) ; Battistoni, G. (INFN, Milan) ; Belcari, N. (Pisa U. ; INFN, Pisa) et al.
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. [...]
2019 - 8 p.
- Published in : Open Physics 17 (2019) 233-240
Fulltext: PDF;
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3.
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The FOOT FragmentatiOn Of Target Experiment
/ Alexandrov, Andrey (INFN, Naples) ; Alpat, Behcet (INFN, Perugia) ; Ambrosi, Giovanni (INFN, Perugia) ; Argirò, Stefano (Turin U. ; INFN, Turin) ; Battistoni, Giuseppe (INFN, Milan) ; Bisogni, Maria Giuseppina (Pisa U. ; INFN, Pisa) ; Belcari, Nicola (Pisa U. ; INFN, Pisa) ; Biondi, Silvia (INFN, Bologna ; Bologna U.) ; Bruni, Graziano (INFN, Bologna) ; Camarlinghi, Niccolò (Pisa U. ; INFN, Pisa) et al.
In proton-therapy clinical practice a constant RBE equal to 1.1 is adopted, regardless of the demonstrated RBE variations, which depends on physical and biological parameters. Among other mechanisms, nuclear interactions might influence the proton-RBE due to secondary heavier particles produced by target fragmentation that can significantly contribute to the total dose: an un-wanted and undetermined increase of normal tissues complications probability may occur. [...]
Geneva : CERN, 2019 - 8 p.
- Published in : CERN Proc.: 1 (2019) , pp. 305-312
Fulltext: PDF;
In : 15th International Conference on Nuclear Reaction Mechanisms, Varenna, Italy, 11 - 15 Jun 2018, pp.305-312
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4.
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Measurement of charged particle yields from therapeutic beams in view of the design of an innovative hadrontherapy dose monitor
/ Battistoni, G (INFN, Milan) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, F (U. Rome La Sapienza (main)) ; Collamati, F (Rome U. ; INFN, Rome) ; Collini, F (INFN, Milan) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Frallicciardi, P M (Enrico Fermi Ctr., Rome) et al.
Particle Therapy (PT) is an emerging technique, which makes use of charged particles to efficiently cure different kinds of solid tumors. The high precision in the hadrons dose deposition requires an accurate monitoring to prevent the risk of under-dosage of the cancer region or of over-dosage of healthy tissues. [...]
2015
- Published in : JINST 10 (2015) C02032
IOP Open Access article: PDF;
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5.
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Measurements of secondary particles emitted by $^{12}$C, $^{4}$He and $^{16}$O ion beams in view of innovative dose profiling technique in Particle Therapy
/ Rucinski, A (INFN, Rome ; U. Rome La Sapienza (main)) ; Battistoni, G (INFN, Milan) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Faccini, R (Rome U. ; INFN, Rome) ; Marafini, M (Rome U. ; INFN, Rome) ; Mattei, I (INFN, Milan) ; Muraro, S (INFN, Milan) ; Paramatti, R (INFN, Rome) ; Patera, V (INFN, Rome ; U. Rome La Sapienza (main) ; Enrico Fermi Ctr., Rome) et al.
Geneva : CERN, 2015
Published version from CERN: PDF;
In : 14th International Conference on Nuclear Reaction Mechanisms, Villa Monastero, Varenna, Italy, 15 - 19 Jun 2015, pp.355
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6.
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Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u12Cbeam
/ Piersanti, L (Frascati ; U. Rome La Sapienza (main)) ; Bellini, F (Rome U. ; INFN, Rome) ; Bini, FU. Rome La Sapienza (main) ; Collamati, F (Rome U. ; INFN, Rome) ; De Lucia, E (Frascati) ; Durante, M (Darmstadt, GSI) ; Faccini, R (Rome U. ; INFN, Rome) ; Ferroni, F (Rome U. ; INFN, Rome) ; Fiore, S (Rome U.) ; Iarocci, E (Frascati ; U. Rome La Sapienza (main)) et al.
The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energetic primary beams interacting with homogeneous tissue like target) have already indicated the correlation that exists between the flux of these secondaries coming from the target (e.g. [...]
2014 - 16.
- Published in : Phys. Med. Biol. 59 (2014) 1857-1872
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7.
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Extended calibration range for prompt photon emission in ion beam irradiation
/ Bellini, F. (Rome U. ; INFN, Rome) ; Boehlen, T.T. (CERN) ; Chin, M.P.W. (CERN) ; Collamati, F. (INFN, Rome ; Rome U.) ; De Lucia, E. (Frascati) ; Faccini, R. (INFN, Rome ; Rome U.) ; Ferrari, A. (CERN) ; Lanza, L. (INFN, Rome ; Rome U.) ; Mancini-Terraciano, C. (Rome III U. ; CERN) ; Marafini, M. (Enrico Fermi Ctr., Rome ; INFN, Rome) et al.
Monitoring the dose delivered during proton and carbon ion therapy is still a matter of research. Among the possible solutions, several exploit the measurement of the single photon emission from nuclear decays induced by the irradiation. [...]
arXiv:1307.5689.-
2014-05-01 - 5 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 745 (2014) 114-118
Elsevier Open Access article: PDF; Fulltext: PDF; External link: Preprint
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8.
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Charged and neutral particles production from an 80 MeV/u 12C ion beam on a PMMA target
/ Agodi, A (INFN, LNS) ; Battistoni, G (INFN, Milan) ; Bellini, F (Rome U. ; INFN, Rome) ; Cirrone, G A P (INFN, LNS) ; Collamati, F (Rome U. ; INFN, Rome) ; Cuttone, G (INFN, LNS) ; De Lucia, E (Frascati) ; De Napoli, M (INFN, LNS) ; Di Domenico, A (Rome U. ; INFN, Rome) ; Faccini, R (Rome U. ; INFN, Rome) et al.
2012
Fulltext: PDF;
In : 13th international conference on nuclear reaction mechanisms, Villa Monastero, Varenna, Italy, 11 - 15 Jun 2012, pp.453
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