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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
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2.
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A Compact Inverse Compton Scattering Source Based on X-band Technology and Cavity-enhanced High Average Power Ultrafast Lasers
/ Latina, Andrea (CERN) ; Cormier, Eric (LP2N, Bordeaux) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN) ; Granados, Eduardo (CERN) ; Grudiev, Alexej (CERN) ; Mușat, Vlad (CERN) ; Santarelli, Giorgio (LP2N, Bordeaux) ; Stapnes, Steinar (CERN) ; Wang, Ping (CERN) et al.
A high-pulse-current photoinjector followed by a short high-gradient X-band linac and a Fabry-Pérot enhancement cavity are considered as a driver for a compact Inverse Compton Scattering (ICS) source. Using a high-power ultra-short pulse laser operating in burst mode in a Fabry-Pérot enhancement cavity, we show that outcoming photons with a total flux over 10$^{13}$ and energies in the MeV range are achievable. [...]
2024 - 4 p.
- Published in : JACoW FLS 2023 (2024) TH4A2
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In : ICFA Advanced Beam Dynamics Workshop on Future Light Sources, Lucerne, Switzerland, 28 Aug - 1 Sep 2023, pp.TH4A2
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3.
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Bubble-beam accelerators: breaking the paradigm
/ Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Dyks, Luke (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Burrows, Philip (JAI, UK) ; Tranchedone, Lorenzo (JAI, UK ; CERN)
Most particle accelerators utilize beams with a charge density concentrated in the center of the bunch in real 3-dimensional space and the 6-dimensional phase space. In this work, by enhancing the space-charge forces in the photo-cathode injector of the Compact Linear Electron Accelerator for Research (CLEAR) at CERN, we produce electron bunches with a “bubble-like” shape, with a charge density mostly concentrated on the outside shell. [...]
2024 - 4 p.
- Published in : JACoW IPAC 2024 (2024) WEPC03
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In : 15th International Particle Accelerator Conference (IPAC 2024), Nashville, TN, United States, 19 - 24 May 2024, pp.WEPC03
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4.
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Application of beam-based alignment to the CLEAR facility
/ Aksoy, Avni (Ankara U. ; CERN) ; Malyzhenkov, Alexander (CERN) ; Latina, Andrea (CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN)
The CERN Linear Electron Accelerator for Research (CLEAR) has been operating since 2017 as a user facility providing beams for a large variety of experiments. Its RF photocathode-based linear accelerator can accelerate electrons up to 220 MeV with a bunch charge of 0.1-1.5nC with single or up to 150 bunches per train. [...]
2023 - 4 p.
- Published in : JACoW IPAC 2023 (2023) WEPL025
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.WEPL025
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5.
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Electron beam test facilities for novel applications
/ Angal-Kalinin, Deepa (Daresbury) ; Mueller, Anke-Susanne (KIT, Karlsruhe) ; Burkart, Florian (DESY) ; Jones, James (Daresbury) ; Schuh, Marcel (KIT, Karlsruhe) ; Pompili, Riccardo (INFN, Milan) ; Corsini, Roberto (CERN) ; Pacey, Thomas (Daresbury) ; Li, Xiangkun (DESY, Zeuthen) ; Stephan, Frank (DESY, Zeuthen)
Delivering and tailoring high brightness electron beams for a wide range of novel applications is a challenging task in single pass accelerator test facilities. This paper will review beam dynamics challenges at single pass accelerator test facilities in Europe to generate, transport and tailor low- to medium-energy high brightness electron beams for a range of novel applications..
2023 - 5 p.
- Published in : JACoW IPAC 2023 (2023) MOZG1
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.MOZG1
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6.
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EuPRAXIA@SPARC_LAB
: Conceptual Design Report
/ Alesini, D (Frascati) ; Anania, M P (Frascati) ; Artioli, M (ENEA, Bologna) ; Bacci, A (INFN, Milan) ; Bartocci, S (Sassari U.) ; Bedogni, R (Frascati) ; Bellaveglia, M (Frascati) ; Biagioni, A (Frascati) ; Bisesto, F (Frascati) ; Brandi, F (CNR, INO, Pisa) et al.
It is widely accepted by the international scientific community that a fundamental milestone towards the realization of a plasma driven future Linear Collider (LC) will be the integration of high gradient accelerating plasma modules in a short wavelength Free Electron Laser (FEL) user facility. [...]
INFN-18-03/LNF.
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2018. - 286 p.
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7.
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
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8.
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CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications
/ Whitmore, L (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech. ; Texas U., Houston) ; Mackay, R I (Manchester U.) ; van Herk, M (Manchester U.) ; Korysko, P (Oxford U. ; CERN) ; Farabolini, W (CERN) ; Malyzhenkov, A (CERN) ; Corsini, R (CERN) ; Jones, R M (Manchester U. ; Cockcroft Inst. Accel. Sci. Tech.)
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. [...]
2024 - 15 p.
- Published in : Sci. Rep. 14 (2024) 11120
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9.
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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10.
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
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