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Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning $^1$H, $^4$He, $^{12}$C, and $^{16}$O ion-beams using an anthropomorphic phantom
/ Mein, Stewart (NCRO, Heidelberg ; Heidelberg U. Hospital ; DKFZ, Heidelberg) ; Kopp, Benedikt (Heidelberg U. Hospital ; Heidelberg U. ; DKFZ, Heidelberg) ; Tessonnier, Thomas (Centre Francois Baclesse, Caen) ; Ackermann, Benjamin (Heidelberg U. Hospital) ; Ecker, Swantje (Heidelberg U. Hospital) ; Bauer, Julia (Heidelberg U. Hospital) ; Choi, Kyungdon (CNAO, Pavia) ; Aricò, Giulia (CERN) ; Ferrari, Alfredo (CERN) ; Haberer, Thomas (Heidelberg U. Hospital) et al.
With high-precision radiotherapy on the rise towards mainstream healthcare, comprehensive validation procedures are essential, especially as more sophisticated technologies emerge. In preparation for the upcoming
translation of novel ions, case-/disease-specific ion-beam selection and advanced multi-particle treatment
modalities at the Heidelberg Ion-beam Therapy Center (HIT), we quantify the accuracy limits in particle therapy
treatment planning under complex heterogeneous conditions for the four ions ($^1$H, $^4$He, $^{12}$C, $^{16}$O) using a Monte
Carlo Treatment Planning platform (MCTP), an independent GPU-accelerated analytical dose engine developed
in-house (FRoG) and the clinical treatment planning system (Syngo RT Planning). [...]
2019 - 9 p.
- Published in : Physica Medica 64 (2019) 123-131
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2.
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An overview of recent developments in FLUKA PET tools
/ Augusto, R S (CERN ; LMU Munich (main)) ; Bauer, J (Heidelberg U. Hospital) ; Bouhali, O (Texas A&M; U. Qatar, Doha) ; Cuccagna, C (CERN ; TERA, Novara ; U. Geneva (main)) ; Gianoli, C (LMU Munich (main)) ; Kozłowska, W S (CERN ; Med. U. of Vienna, Spitalgasse) ; Ortega, P G (U. Salamanca (main)) ; Tessonnier, T (Centre François Baclesse, Caen) ; Toufique, Y (Texas A&M; U. Qatar, Doha ; Hassan 1st U., Settat) ; Vlachoudis, V (CERN) et al.
The new developments of the FLUKA Positron-Emission-Tomography (PET) tools are detailed. FLUKA is a fully integrated Monte Carlo (MC) particle transport code, used for an extended range of applications, including Medical Physics. [...]
2018
- Published in : Physica Medica 54 (2018) 189-199
Fulltext: PDF;
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A phenomenological relative biological effectiveness approach for proton therapy based on an improved description of the mixed radiation field
/ Mairani, A (CNAO Foundation, Pavia ; HIT, Heidelberg) ; Dokic, I (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Magro, G (CNAO Foundation, Pavia) ; Tessonnier, T (Munich U. ; Heidelberg, Inst. Radiology) ; Bauer, J (HIT, Heidelberg ; Heidelberg, Inst. Radiology) ; Böhlen, TT (EBG GmbH MedAustron, Austria) ; Ciocca, M (CNAO Foundation, Pavia) ; Ferrari, A (CERN) ; Sala, P R (INFN, Milan) ; Jäkel, O (HIT, Heidelberg ; Heidelberg, Inst. Radiology) et al.
Proton therapy treatment planning systems (TPSs) are based on the assumption of a constant relative biological effectiveness (RBE) of 1.1 without taking into account the found in vitro experimental variations of the RBE as a function of tissue type, linear energy transfer (LET) and dose. The phenomenological RBE models available in literature are based on the dose-averaged LET (LET D ) as an indicator of the physical properties of the proton radiation field. [...]
2017 - 18 p.
- Published in : Phys. Med. Biol. 62 (2017) 1378-1395
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4.
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Variable RBE in proton therapy: comparison of different model predictions and their influence on clinical-like scenarios
/ Giovannini, Giulia (Munich U. ; Pavia U. ; Heidelberg, Inst. Radiology) ; Böhlen, Till (CERN ; Munich U. ; Fachhochsch., Wiener Neustadt) ; Cabal, Gonzalo (Munich U.) ; Bauer, Julia (Heidelberg Ion-Beam Therapy Center (HIT) ; Heidelberg, Inst. Radiology) ; Tessonnier, Thomas (Heidelberg, Inst. Radiology) ; Frey, Kathrin (Munich U.) ; Debus, Jürgen (Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Mairani, Andrea (CNAO Foundation, Pavia ; Heidelberg Ion-Beam Therapy Center (HIT)) ; Parodi, Katia (Munich U. ; Heidelberg, Inst. Radiology ; Heidelberg Ion-Beam Therapy Center (HIT))
Background: In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy transfer (LET) and tissue type. [...]
2016 - 16 p.
- Published in : Radiat. Oncol. 11 (2016) 68
Fulltext: PDF;
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5.
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The FLUKA code: An accurate simulation tool for particle therapy
/ Battistoni, Giuseppe (INFN, Milan) ; Bauer, Julia (Uniklinikum, Heidelberg) ; Böhlen, Till T (Uniklinikum, Heidelberg) ; Cerutti, Francesco (CERN) ; Chin, Mary Pik Wai (CERN) ; Dos Santos Augusto, Ricardo M (LMU Munich (main) ; CERN) ; Ferrari, Alfredo (CERN) ; Garcia Ortega, Pablo (CERN) ; Kozlowska, Wioletta S (HIT, Heidelberg ; CERN) ; Magro, Giuseppe (CNAO, Milan) et al.
Monte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability of a MC code for application to hadrontherapy demands accurate and reliable physical models capable of handling all components of the expected radiation field. [...]
2016
- Published in : Front. Oncol. 6 (2016) 116
Frontiers Open Access article: PDF;
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6.
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A Monte Carlo-based treatment-planning tool for ion beam therapy
/ Böhlen, T T (CERN ; Stockholm U. ; Karolinska Inst., Stockholm) ; Bauer, J (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic) ; Dosanjh, M (CERN) ; Ferrari, A (CERN) ; Haberer, T (Heidelberg Ion-Beam Therapy Center, Heidelberg) ; Parodi, K (Heidelberg Ion-Beam Therapy Center, Heidelberg ; Heidelberg University Clinic ; Munich U.) ; Patera, V (U. Rome La Sapienza) ; Mairan, A (CNAO, Pavia)
Ion beam therapy, as an emerging radiation therapy modality, requires continuous efforts to develop and improve tools for patient treatment planning (TP) and research applications. Dose and fluence computation algorithms using the Monte Carlo (MC) technique have served for decades as reference tools for accurate dose computations for radiotherapy. [...]
2013
- Published in : J. Radiat. Res. 54 (2013) i77-i81
Oxford Univ. Press Open Access article: PDF;
In : PARTNER, pp.i77-i81
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7.
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8.
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9.
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Exclusive $\gamma\gamma \to \mu^{+}\mu^{-}$ production in proton-proton collisions at $\sqrt{s}$ = 7 TeV
/ CMS Collaboration
A measurement of the exclusive two-photon production of muon pairs in proton-proton collisions at $\sqrt{s}$=7 TeV, pp → pμ + μ −p, is reported using data corresponding to an integrated luminosity of 40 pb−1. For muon pairs with invariant mass greater than 11.5 GeV, transverse momentum p T (μ) > 4 GeV and pseudorapidity |η(μ)| < 2.1, a fit to the dimuon p T (μ + μ −) distribution results in a measured cross section of σ(p → pμ + μ −p) = 338+058−055 (stat.) ± 0.16 (syst.) ± 0.14 (lumi.) pb, consistent with the theoretical prediction evaluated with the event generator Lpair. [...]
arXiv:1111.5536; CERN-PH-EP-2011-187; CMS-FWD-10-005; CMS-FWD-10-005; CERN-PH-EP-2011-187.-
Geneva : CERN, 2012 - 35 p.
- Published in : JHEP 01 (2012) 052
Fulltext: PDF; Springer Open Access article: PDF; External link: Rivet analyses reference
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10.
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J/$\psi$ and $\psi$(2S) production in pp collisions at $\sqrt{s}$ = 7 TeV
/ CMS Collaboration
A measurement of the J/$\psi$ and psi(2S) production cross sections in pp collisions at $\sqrt{s}$=7 TeV with the CMS experiment at the LHC is presented. The data sample corresponds to an integrated luminosity of 37 inverse picobarns. [...]
arXiv:1111.1557; CMS-BPH-10-014; CERN-PH-EP-2011-177; CMS-BPH-10-014; CERN-PH-EP-2011-177.-
Geneva : CERN, 2012 - 39 p.
- Published in : JHEP 02 (2012) 011
Fulltext: fermilab-pub-11-745-cms - PDF; fermi - PDF; arXiv:1111.1557 - PDF; Springer Open Access article: PDF; External link: DURHAM
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