5-Metiluridin trifosfat
5-Metiluridin trifosfat je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 498,168 Da.
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| Klinički podaci | |||
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| AHFS/Drugs.com | triphosphate.html Monografija | ||
| Identifikatori | |||
| CAS broj | ? | ||
| ATC kod | ? | ||
| ChEMBL[1] | CHEMBL607677 
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| Hemijski podaci | |||
| Formula | C10H17N2O15P3 | ||
| Mol. masa | 498,168 | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
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Osobine
uredi| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 15 |
| Broj donora vodonika | 7 |
| Broj rotacionih veza | 8 |
| Particioni koeficijent[2] (ALogP) | -2,6 |
| Rastvorljivost[3] (logS, log(mol/L)) | 1,5 |
| Polarna površina[4] (PSA, Å2) | 288,3 |
Reference
uredi- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.
Literatura
uredi- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.