Furosemid
|
|
| (IUPAC) ime
|
| 4-hloro-2-(furan-2-ilmetilamino)- 5-sulfamoilbenzojeva kiselina
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| Klinički podaci
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| Identifikatori
|
| CAS broj
|
54-31-9
|
| ATC kod
|
C03CA01
|
| PubChem[1][2]
|
3440
|
| DrugBank
|
DB00695
|
| ChemSpider[3]
|
3322
|
| UNII
|
7LXU5N7ZO5  Y
|
| KEGG[4]
|
D00331 Y
|
| ChEBI
|
CHEBI:47426 Y
|
| ChEMBL[5]
|
CHEMBL35 Y
|
| Hemijski podaci
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| Formula
|
C12H11ClN2O5S
|
| Mol. masa
|
330,745 g/mol
|
| SMILES
|
eMolekuli & PubHem
|
| InChI |
|---|
InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) Y
Key: ZZUFCTLCJUWOSV-UHFFFAOYSA-N Y |
|
| Farmakokinetički podaci
|
| Bioraspoloživost
|
43-69%
|
| Metabolizam
|
hepatički i renalna glukuronidacija
|
| Poluvreme eliminacije
|
do 100 minuta
|
| Izlučivanje
|
renalno 66%, bilijarno 33%
|
| Farmakoinformacioni podaci
|
| Licenca
|
US Daily Med:link
|
| Trudnoća
|
C(AU) C(US)
|
| Pravni status
|
℞ Prescription only
|
| Način primene
|
Oralno, IV, IM
|
Furosemid[6] ili frusemid je diuretik Henleove petlje koji se koristi u tretmanu kongestivnog zatajenja srca i edema. Ovaj lek proizvodi i prodaje preduzeće Sanofi pod imenom Lasix. On je takođe dostupan pod imenima Fusid i Frumex.[7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Changes to medicines names: BANs to rINNs
- ↑ Frumex
Šablon:Diuretici
„Golan” preusmjerava ovdje. Za visoravan, v. Golan (visoravan).
