S6 kinase 1 regulates estrogen receptor α in control of breast cancer cell proliferation
RL Yamnik, A Digilova, DC Davis, ZN Brodt… - Journal of Biological …, 2009 - ASBMB
The 40 S ribosomal S6 kinase 1 (S6K1) acts downstream of mTOR (mammalian target of
rapamycin) and is sensitive to inhibition by rapamycin. The chromosomal region 17q23
containing the RPS6KB1 gene is frequently amplified in breast cancer cells, leading to S6K1
overexpression. The role of S6K1 in disease development and progression is supported by
the observation that S6K1 overexpression is associated with poor prognosis in breast
cancer patients. However, the identity of mammary cell-specific S6K1 targets is not well …
rapamycin) and is sensitive to inhibition by rapamycin. The chromosomal region 17q23
containing the RPS6KB1 gene is frequently amplified in breast cancer cells, leading to S6K1
overexpression. The role of S6K1 in disease development and progression is supported by
the observation that S6K1 overexpression is associated with poor prognosis in breast
cancer patients. However, the identity of mammary cell-specific S6K1 targets is not well …