Role of D-galactose-induced brain aging and its potential used for therapeutic interventions
T Shwe, W Pratchayasakul, N Chattipakorn… - Experimental …, 2018 - Elsevier
Aging is a phenomenon that all living organisms inevitably face. Every year, 9.9 million
people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is
significantly associated with mitochondrial dysfunction. This is characterized by a decrease
in the activity of respiratory chain enzymes and ATP production, and increased free radical
generation, mitochondrial deoxyribonucleic acid (DNA) mutations, and impaired
mitochondrial structures. To get a better understanding of aging and to prevent its effects on …
people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is
significantly associated with mitochondrial dysfunction. This is characterized by a decrease
in the activity of respiratory chain enzymes and ATP production, and increased free radical
generation, mitochondrial deoxyribonucleic acid (DNA) mutations, and impaired
mitochondrial structures. To get a better understanding of aging and to prevent its effects on …