[HTML][HTML] New insights into structural disorder in human respiratory syncytial virus phosphoprotein and implications for binding of protein partners
N Pereira, C Cardone, S Lassoued, M Galloux… - Journal of Biological …, 2017 - ASBMB
Phosphoprotein is the main cofactor of the viral RNA polymerase of Mononegavirales. It is
involved in multiple interactions that are essential for the polymerase function. Most
prominently it positions the polymerase complex onto the nucleocapsid, but also acts as a
chaperone for the nucleoprotein. Mononegavirales phosphoproteins lack sequence
conservation, but contain all large disordered regions. We show here that N-and C-terminal
intrinsically disordered regions account for 80% of the phosphoprotein of the respiratory …
involved in multiple interactions that are essential for the polymerase function. Most
prominently it positions the polymerase complex onto the nucleocapsid, but also acts as a
chaperone for the nucleoprotein. Mononegavirales phosphoproteins lack sequence
conservation, but contain all large disordered regions. We show here that N-and C-terminal
intrinsically disordered regions account for 80% of the phosphoprotein of the respiratory …