Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox-state
M Glanemann, B Vollmar, AK Nussler, T Schaefer… - Journal of …, 2003 - Elsevier
Background/Aims: Ischemic preconditioning (IP) is known to protect hepatic tissue from
ischemia–reperfusion injury. However, the mechanisms involved are not fully understood
yet. Methods: Using intravital multifluorescence microscopy in the rat liver, we studied
whether IP exerts its beneficial effect by modulating postischemic Kupffer cell activation,
leukocyte–endothelial cell interaction, microvascular no-reflow, mitochondrial redox state,
and, thus, tissue oxygenation. Results: Portal triad cross-clamping (45 min) followed by …
ischemia–reperfusion injury. However, the mechanisms involved are not fully understood
yet. Methods: Using intravital multifluorescence microscopy in the rat liver, we studied
whether IP exerts its beneficial effect by modulating postischemic Kupffer cell activation,
leukocyte–endothelial cell interaction, microvascular no-reflow, mitochondrial redox state,
and, thus, tissue oxygenation. Results: Portal triad cross-clamping (45 min) followed by …