Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
CA Camargo Jr, JF Madden, W Gao, RS Selvan… - Hepatology, 1997 - journals.lww.com
Abstract Interleukin-6 (IL-6) is an acute reactant cytokine with anti-inflammatory properties,
which has been found to prevent injury in a model of acute hepatitis in mice through
downregulation of tumor necrosis factor α (TNF-α); to correlate inversely with markers of
hepatocellular injury in patients with liver ischemia; and to initiate liver regeneration in mice.
In this study, we investigated the role of IL-6 in rodent models of hepatic warm
ischemia/reperfusion (WI/Rp) injury. IL-6-deficient mice (-/-) were subjected to hepatic WI …
which has been found to prevent injury in a model of acute hepatitis in mice through
downregulation of tumor necrosis factor α (TNF-α); to correlate inversely with markers of
hepatocellular injury in patients with liver ischemia; and to initiate liver regeneration in mice.
In this study, we investigated the role of IL-6 in rodent models of hepatic warm
ischemia/reperfusion (WI/Rp) injury. IL-6-deficient mice (-/-) were subjected to hepatic WI …