In this paper, we evaluate the reliability of the You Only Look Once (YOLO) object detection framework. We have exposed to controlled neutron beams GPUs designed with three different architectures (Kepler, Maxwell, and Pascal) running Darknet, a Convolutional Neural Network for automotive applications, detecting objects in both Caltech and Visual Object Classes data sets. By analyzing the neural network corrupted output, we can distinguish between tolerable errors and critical errors, i.e., errors that could impact on real-time system execution. Additionally, we propose an Algorithm-Based Fault-Tolerance (ABFT) strategy to apply to the matrix multiplication kernels of neural networks able to detect and correct 50% to 60% of radiation induced corruptions. We experimentally validate our hardening solution and compare its efficiency and efficacy with the available ECC.