Characterization of mammalian selenoproteomes
GV Kryukov, S Castellano, SV Novoselov, AV Lobanov… - Science, 2003 - science.org
Science, 2003•science.org
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no
computational methods for identifying its coding function are available. Consequently, most
selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced
mammalian genomes by methods that rely on identification of selenocysteine insertion RNA
structures, the coding potential of UGA codons, and the presence of cysteine-containing
homologs. The human selenoproteome consists of 25 selenoproteins.
computational methods for identifying its coding function are available. Consequently, most
selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced
mammalian genomes by methods that rely on identification of selenocysteine insertion RNA
structures, the coding potential of UGA codons, and the presence of cysteine-containing
homologs. The human selenoproteome consists of 25 selenoproteins.
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.