VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor
LW Wu, LD Mayo, JD Dunbar, KM Kessler… - Journal of Biological …, 2000 - ASBMB
A protein that binds the intracellular domain of KDR (KDR-IC), a receptor for vascular
endothelial cell growth factor (VEGF), was identified by two-hybrid screening. Two-hybrid
mapping showed that the VEGF receptor-associated protein (VRAP) interacted with tyrosine
951 in the kinase insert domain of KDR. Northern blot analysis identified multiple VRAP
transcripts in peripheral leukocytes, spleen, thymus, heart, lung, and human umbilical vein
endothelial cells (HUVEC). The predominant VRAP mRNA encodes a 389-amino acid …
endothelial cell growth factor (VEGF), was identified by two-hybrid screening. Two-hybrid
mapping showed that the VEGF receptor-associated protein (VRAP) interacted with tyrosine
951 in the kinase insert domain of KDR. Northern blot analysis identified multiple VRAP
transcripts in peripheral leukocytes, spleen, thymus, heart, lung, and human umbilical vein
endothelial cells (HUVEC). The predominant VRAP mRNA encodes a 389-amino acid …