Variant histones that differ in amino acid sequence from S-phase histones are widespread in
eukaryotes, yet the structural changes they cause to nucleosomes and how those changes
affect relevant cellular processes have not been determined. H2A. F/Z is a highly conserved
family of H2A variants. H2Av, the H2A. F/Z variant of Drosophila melanogaster, was
localized in polytene chromosomes by indirect immunofluorescence and in diploid
chromosomes by chromatin immunoprecipitation. H2Av was widely distributed in the …