Evidence that the “NF” motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2
SH Kim, SS Sisodia - Journal of Biological Chemistry, 2005 - ASBMB
Macromolecular complexes containing presenilins (PS1 and PS2), nicastrin, anterior
pharynx defective phenotype 1 (APH-1), and PS enhancer 2 (PEN-2) mediate the
intramembranous, γ-secretase cleavage of β-amyloid precursor protein (APP), Notch, and a
variety of type 1 membrane proteins. We previously demonstrated that PEN-2 is critical for
promoting endoproteolysis of PS1 and that the proximal two-thirds of transmembrane
domain (TMD) 1 of PEN-2 is required for binding with PS1. In this study, we sought to identify …
pharynx defective phenotype 1 (APH-1), and PS enhancer 2 (PEN-2) mediate the
intramembranous, γ-secretase cleavage of β-amyloid precursor protein (APP), Notch, and a
variety of type 1 membrane proteins. We previously demonstrated that PEN-2 is critical for
promoting endoproteolysis of PS1 and that the proximal two-thirds of transmembrane
domain (TMD) 1 of PEN-2 is required for binding with PS1. In this study, we sought to identify …