Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk
C Garcés, MJ Ruiz-Hidalgo, E Bonvini, J Goldstein… - Differentiation, 1999 - Elsevier
Previous studies demonstrate that the delta-like (dlk) and preadipocyte factor 1 (Pref-1)
genes encode similar proteins. Pref-1 is downregulated during adipocyte differentiation, and
expression of ectopic Pref-1 inhibits adipogenesis. We explored whether dlk functions
similarly to Pref-1 and studied the role of alternately spliced dlk variants encoding
membrane-associated or-secreted forms. We also studied whether enforced down-
regulation of dlk/Pref-1 may enhance the differentiation response of non-committed cells …
genes encode similar proteins. Pref-1 is downregulated during adipocyte differentiation, and
expression of ectopic Pref-1 inhibits adipogenesis. We explored whether dlk functions
similarly to Pref-1 and studied the role of alternately spliced dlk variants encoding
membrane-associated or-secreted forms. We also studied whether enforced down-
regulation of dlk/Pref-1 may enhance the differentiation response of non-committed cells …