Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients
CW Ha, MJ Noh, KB Choi, KH Lee - Cytotherapy, 2012 - Elsevier
Abstract Background aims TissueGene-C (TG-C) represents a cell-mediated gene therapy
for localized delivery of allogeneic chondrocytes expressing transforming growth factor
(TGF)-β1 directly to the damaged knee joint. Untransduced human chondrocytes (hChonJ
cells) have also been incorporated into the TG-C product at a 3: 1 ratio with TGF-β1-
expressing chondrocytes (hChonJb# 7) in order to help fill in the defect and as target cells
for the actions of the expressed TGF-β1. Methods A phase I dose-escalating clinical trial was …
for localized delivery of allogeneic chondrocytes expressing transforming growth factor
(TGF)-β1 directly to the damaged knee joint. Untransduced human chondrocytes (hChonJ
cells) have also been incorporated into the TG-C product at a 3: 1 ratio with TGF-β1-
expressing chondrocytes (hChonJb# 7) in order to help fill in the defect and as target cells
for the actions of the expressed TGF-β1. Methods A phase I dose-escalating clinical trial was …