Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases
CE Egwuagu, CR Yu, L Sun, R Wang - Cytokine & growth factor reviews, 2015 - Elsevier
Cytokines coordinate the activities of innate and adaptive immune systems and the
Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in
infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated
with the pathogenesis of chronic inflammatory diseases, others (IL-27 and IL-35) mitigate
autoimmune diseases. Unlike IL-12, IL-23 and IL-27 that are produced mainly by antigen
presenting cells, IL-35 is predominantly secreted by regulatory B (i35-Bregs) and T (iTR35) …
Interleukin 12 (IL-12) family of cytokines has emerged as critical regulators of immunity in
infectious and autoimmune diseases. While some members (IL-12 and IL-23) are associated
with the pathogenesis of chronic inflammatory diseases, others (IL-27 and IL-35) mitigate
autoimmune diseases. Unlike IL-12, IL-23 and IL-27 that are produced mainly by antigen
presenting cells, IL-35 is predominantly secreted by regulatory B (i35-Bregs) and T (iTR35) …