Scavenger receptor Bl and cholesterol trafficking
DL Williams, MA Connelly, RE Temel… - Current opinion in …, 1999 - journals.lww.com
Current opinion in lipidology, 1999•journals.lww.com
Abstract Scavenger receptor Bl (SR-BI) mediates the selective uptake of HDL cholesteryl
ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL
concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of
apolipoprotein B-containing particles and influences the development of atherosclerosis in
several animal models. These results and the similar pattern of SR-BI expression in humans
emphasize that it is important to learn how this receptor influences lipoprotein metabolism …
ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL
concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of
apolipoprotein B-containing particles and influences the development of atherosclerosis in
several animal models. These results and the similar pattern of SR-BI expression in humans
emphasize that it is important to learn how this receptor influences lipoprotein metabolism …
Abstract
Scavenger receptor Bl (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.