Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events
W Scheper, R Zwart, F Baas - Molecular brain research, 2004 - Elsevier
Processing of the amyloid precursor protein (APP) by α-secretase precludes the formation of
β-amyloid (Aβ). Therefore, the increase of cleavage by α-secretase upon stimulation by
protein kinase C (PKC) is of potential therapeutic interest for Alzheimer's disease (AD).
Unknown is whether phosphorylation by PKC increases α-secretase-mediated cleavage
directly or indirectly, for example, by modulation of APP trafficking. Because modulation of
Rab6-mediated transport has been shown to affect APP processing, we investigated the …
β-amyloid (Aβ). Therefore, the increase of cleavage by α-secretase upon stimulation by
protein kinase C (PKC) is of potential therapeutic interest for Alzheimer's disease (AD).
Unknown is whether phosphorylation by PKC increases α-secretase-mediated cleavage
directly or indirectly, for example, by modulation of APP trafficking. Because modulation of
Rab6-mediated transport has been shown to affect APP processing, we investigated the …