Antiviral activity of substituted homoisoflavonoids on enteroviruses
S Tait, AL Salvati, N Desideri, L Fiore - Antiviral research, 2006 - Elsevier
S Tait, AL Salvati, N Desideri, L Fiore
Antiviral research, 2006•ElsevierThe antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro
against a large panel of enteroviruses. The inhibition of viral replication was monitored on
BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50),
as well as the selectivity index (SI) were determined. None of the substances were effective
against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a
marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
against a large panel of enteroviruses. The inhibition of viral replication was monitored on
BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50),
as well as the selectivity index (SI) were determined. None of the substances were effective
against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a
marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
Elsevier