Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
RMD Holsinger, CA McLean… - Annals of neurology …, 2002 - Wiley Online Library
Annals of neurology: Official journal of the American neurological …, 2002•Wiley Online Library
Abstract β‐Secretase cleavage represents the first step in the generation of Aβ polypeptides
and initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease.
By comparative Western blot analysis, we show a 2.7‐fold increase in protein expression of
the β‐secretase enzyme BACE in the brain cortex of Alzheimer's disease patients as
compared to age‐matched controls. Similarly, we found the levels of the amyloid precursor
protein C‐terminal fragment produced by β‐secretase to be increased by nearly twofold in …
and initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease.
By comparative Western blot analysis, we show a 2.7‐fold increase in protein expression of
the β‐secretase enzyme BACE in the brain cortex of Alzheimer's disease patients as
compared to age‐matched controls. Similarly, we found the levels of the amyloid precursor
protein C‐terminal fragment produced by β‐secretase to be increased by nearly twofold in …
Abstract
β‐Secretase cleavage represents the first step in the generation of Aβ polypeptides and initiates the amyloid cascade that leads to neurodegeneration in Alzheimer's disease. By comparative Western blot analysis, we show a 2.7‐fold increase in protein expression of the β‐secretase enzyme BACE in the brain cortex of Alzheimer's disease patients as compared to age‐matched controls. Similarly, we found the levels of the amyloid precursor protein C‐terminal fragment produced by β‐secretase to be increased by nearly twofold in Alzheimer's disease cortex.