The next-generation mobile network will support terminal mobility, personal mobility, and service provider portability, making global roaming seamless. A location-independent personal telecommunication number (PTN) scheme is conducive to implementing such a global mobile system. However, the nongeographic PTNs coupled with the anticipated large number of mobile users in future mobile networks may introduce very large centralized databases. This necessitates research into the design and performance of high-throughput database technologies used in mobile systems to ensure that future systems will be able to carry efficiently the anticipated loads. This paper proposes a scalable, robust, efficient location database architecture based on the location-independent PTNs. The proposed multitree database architecture consists of a number of database subsystems, each of which is a three-level tree structure and is connected to the others only through its root. By exploiting the localized nature of calling and mobility patterns, the proposed architecture effectively reduces the database loads as well as the signaling traffic incurred by the location registration and call delivery procedures. In addition, two memory-resident database indices, memory-resident direct file and T-tree, are proposed for the location databases to further improve their throughput. Analysis model and numerical results are presented to evaluate the efficiency of the proposed database architecture. Results have revealed that the proposed database architecture for location management can effectively support the anticipated high user density in the future mobile networks.