Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis
AV Nairn, K Aoki, M dela Rosa, M Porterfield… - Journal of Biological …, 2012 - ASBMB
The abundance and structural diversity of glycans on glycoproteins and glycolipids are
highly regulated and play important roles during vertebrate development. Because of the
challenges associated with studying glycan regulation in vertebrate embryos, we have
chosen to study mouse embryonic stem (ES) cells as they differentiate into embryoid bodies
(EBs) or into extraembryonic endodermal (ExE) cells as a model for cellular differentiation.
We profiled N-and O-glycan structures isolated from these cell populations and examined …
highly regulated and play important roles during vertebrate development. Because of the
challenges associated with studying glycan regulation in vertebrate embryos, we have
chosen to study mouse embryonic stem (ES) cells as they differentiate into embryoid bodies
(EBs) or into extraembryonic endodermal (ExE) cells as a model for cellular differentiation.
We profiled N-and O-glycan structures isolated from these cell populations and examined …