A new model for limb development which incorporates both outgrowth due to cell growth
and division, and interactions between morphogens produced in the zone of polarizing
activity (ZPA) and the apical epidermal ridge (AER) is developed and analysed. The
numerically-computed spatio-temporal distributions of these morphogens demonstrate the
importance of interaction between the organizing regions in establishing the morphogenetic
terrain on which cells reside, and because growth is explicitly incorporated, it is found that …