This paper deals with data-driven output syn-chronization for heterogeneous leader-follower linear multi-agent systems. Given a multi-agent system that consists of one autonomous leader and a number of heterogeneous followers with external disturbances, we provide necessary and sufficient data-based conditions for output synchronization. We also provide a design method for obtaining such output synchronizing protocols directly from data. The results are then extended to the special case that the followers are disturbance-free. Finally, a simulation example is provided to illustrate our results.