Background Major depressive disorder (MDD) affects women approximately twice as often
as men. Women are three times as likely to have atypical depression, with hypersomnia and …

With the rapid advances and prevalence of high-throughput genomic technologies, integrating
information of multiple relevant genomic studies has brought new challenges. Microarray …

Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing
events (RNA level). They have been recognized as a promising tool for diagnosing, …

Recent advances in large-scale gene expression profiling necessitate concurrent development
of biostatistical approaches to reveal meaningful biological relationships. Most analyses …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize
the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are …

The development of Alzheimer's dementia (AD) accompanies both central and peripheral
metabolic disturbance, but the metabolic basis underlying AD and metabolic markers …

Objective Many children with autism spectrum disorder (ASD) have feeding and mealtime
problems. To address these, we conducted a pilot randomized trial of a new 11-session, …

Circadian rhythms are generated by an autoregulatory feedback loop of transcriptional
activators and repressors. Circadian rhythm disruption contributes to type 2 diabetes (T2D) …

Schizophrenia (SZ) is associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC).
This dysfunction is manifest as cognitive deficits that appear to arise from disturbances in …