Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer

Z Liu, L Liu, S Weng, C Guo, Q Dang, H Xu… - Nature …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology in
colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs …

Immunosenescence: molecular mechanisms and diseases

Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts

…, J Hu, P Luo, J Zhang, Z Liu, Y Peng, Z Liu… - Journal of Hematology & …, 2022 - Springer
The discovery of immune checkpoint inhibitors (ICIs) has now been universally acknowledged
as a significant breakthrough in tumor therapy after the targeted treatment of checkpoint …

Multi-stage mechanisms of tumor metastasis and therapeutic strategies

Z Liu, J Chen, Y Ren, S Liu, Y Ba, A Zuo… - … and Targeted Therapy, 2024 - nature.com
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ-…

Integrative analysis from multi-center studies identities a consensus machine learning-derived lncRNA signature for stage II/III colorectal cancer

Z Liu, CG Guo, Q Dang, L Wang, L Liu, S Weng, H Xu… - …, 2022 - thelancet.com
Background Long non-coding RNAs (lncRNAs) have recently emerged as essential biomarkers
of cancer progression. However, studies are limited regarding lncRNAs correlated with …

Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma

…, L Zhang, Z Liu, J Zhang, P Luo, Z Liu… - Briefings in …, 2022 - academic.oup.com
Long noncoding ribonucleic acids (RNAs; lncRNAs) have been associated with cancer
immunity regulation. However, the roles of immune cell-specific lncRNAs in glioblastoma (GBM) …

Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Q Dang, Z Sun, Y Wang, L Wang, Z Liu, X Han - Cell death & disease, 2022 - nature.com
The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

Biological and pharmacological roles of m6A modifications in cancer drug resistance

Z Liu, H Zou, Q Dang, H Xu, L Liu, Y Zhang, J Lv, H Li… - Molecular Cancer, 2022 - Springer
Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant
cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological …

Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy

Z Liu, Z Zhou, Q Dang, H Xu, J Lv, H Li, X Han - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
Chimeric antigen receptor (CAR)-T cell therapy represents a landmark advance in personalized
cancer treatment. CAR-T strategy generally engineers T cells from a specific patient with …