User profiles for Yi-Chun Kuo

YI-CHUN KUO

Takeda pharmaceutical
Verified email at TAKEDA.COM
Cited by 530

Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55α regulatory subunit targeting of the protein phosphatase 2A holoenzyme to …

YC Kuo, KY Huang, CH Yang, YS Yang, WY Lee… - Journal of Biological …, 2008 - ASBMB
Akt is a protein serine/threonine kinase that is involved in the regulation of diverse cellular
processes. Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full …

Regulation of vascular smooth muscle cell turnover by endothelial cell–secreted microRNA-126: role of shear stress

…, YS Li, P Nguyen, KC Wang, A Weiss, YC Kuo… - Circulation …, 2013 - Am Heart Assoc
Rationale: Endothelial microRNA-126 (miR-126) modulates vascular development and
angiogenesis. However, its role in the regulation of smooth muscle cell (SMC) function is …

The Lectin Receptor Kinase-VI.2 Is Required for Priming and Positively Regulates Arabidopsis Pattern-Triggered Immunity

P Singh, YC Kuo, S Mishra, CH Tsai, CC Chien… - The Plant …, 2012 - academic.oup.com
Plant cells can be sensitized toward a subsequent pathogen attack by avirulent pathogens
or by chemicals such as β-aminobutyric acid (BABA). This process is called priming. Using a …

Referring image segmentation via recurrent refinement networks

R Li, K Li, YC Kuo, M Shu, X Qi… - Proceedings of the …, 2018 - openaccess.thecvf.com
We address the problem of image segmentation from natural language descriptions. Existing
deep learning-based methods encode image representations based on the output of the …

Effects of cooking method, cooking oil, and food type on aldehyde emissions in cooking oil fumes

CY Peng, CH Lan, PC Lin, YC Kuo - Journal of hazardous materials, 2017 - Elsevier
Cooking oil fumes (COFs) contain a mixture of chemicals. Of all chemicals, aldehydes draw
a great attention since several of them are considered carcinogenic and formation of long-…

Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration

…, I Nassour, X Liu, J Xu, M Wu, Y Zhao, YC Kuo… - Cell stem cell, 2016 - cell.com
Mammals have partially lost the extensive regenerative capabilities of some vertebrates,
possibly as a result of chromatin-remodeling mechanisms that enforce terminal differentiation. …

Sorting nexin 5 mediates virus-induced autophagy and immunity

…, Y Zhao, B Ci, L Zhong, M Bhave, L Wang, YC Kuo… - Nature, 2021 - nature.com
Autophagy, a process of degradation that occurs via the lysosomal pathway, has an essential
role in multiple aspects of immunity, including immune system development, regulation of …

Separation of long double-stranded DNA by nanoparticle-filled capillary electrophoresis

MF Huang, YC Kuo, CC Huang, HT Chang - Analytical chemistry, 2004 - ACS Publications
We present the first example of the analysis of long double-stranded (ds) DNA molecules by
nanoparticle-filled capillary electrophoresis (NFCE). To avoid aggregation of the gold …

High-throughput screens to identify autophagy inducers that function by disrupting Beclin 1/Bcl-2 binding

WC Chiang, Y Wei, YC Kuo, S Wei, A Zhou… - ACS chemical …, 2018 - ACS Publications
Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis,
development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, …

Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells

YC Kuo, TH Chang, WT Hsu, J Zhou, HH Lee… - Stem …, 2015 - academic.oup.com
Shear stress stimuli differentially regulate cellular functions based on the pattern, magnitude
as well as duration of the flow. Shear stress can modify intracellular kinase activities and …