In the present study, we investigated the activity of XL388, a novel mammalian target of
rapamycin (mTOR) complex 1/2 (mTORC1/2) dual inhibitor, in preclinical osteosarcoma (OS) …

The search for novel and more efficient chemo-agents against malignant osteoblastoma is
important. In this study, we examined the potential anti-osteoblastoma function of bufotalin, …

Recent studies have identified that constitutively active phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian
target of rapamycin (mTOR) signaling is an important feature of …

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the
post-transcriptional level, and play pivotal roles in cancer development and progression. miR-…

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules.
Recent advances have enabled its application in cancer research and diagnosis. The …

Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern
Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3…

The hub bearing with face spline transmission is a new type of hub bearing. The design
method and standards are lack. In this work, the geometric relationship of the tooth profile …

Tumor immune escape is an important strategy of tumor survival. There are many mechanisms
of tumor immune escape, including immunosuppression, which has become a research …

Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …