Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at
2p23 result in fusion with various partner genes leading to aberrant production of oncogenic …

Renal cell carcinoma (RCC) with chromosomal rearrangement of transcription factor for
immunoglobulin heavy-chain enhancer 3 (TFE3) at Xp11. 2 is a distinct subtype that was initially …

SPOP mutations and TMPRSS2-ERG rearrangements occur collectively in up to 65% of
human prostate cancers. Although the two events are mutually exclusive, it is unclear whether …

Purpose : We determined the clinical and pathological features associated with death from
papillary renal cell carcinoma in 395 surgically treated patients. Materials and Methods : …

TFE3 translocation–associated PEComa is a distinct form of perivascular epithelioid cell
neoplasm, the features of which are poorly defined owing to their general infrequency and …

Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2
protein expression and gene amplification in patients with curatively resected esophageal …

Dense deposit disease (DDD) is a rare glomerular disease that typically affects children,
young adults, and much less commonly, older patients. The pathophysiologic process …

Gastroblastoma is a rare distinctive biphasic tumor of the stomach. The molecular biology of
gastroblastoma has not been studied, and no affirmative diagnostic markers have been …

MYC, a proto-oncogene located on chromosome 8q24, is involved in the control of cell
proliferation and differentiation. Previous studies have documented high-level MYC gene …

It has been reported that Fuhrman grading is not appropriate for chromophobe renal cell
carcinoma (RCC). The objective of this study was to determine whether nucleolar grading and …