Automated physics-based design of synthetic riboswitches from diverse RNA aptamers

…, DM Mishler, J Wang, W Huso… - Nucleic acids …, 2016 - academic.oup.com
Riboswitches are shape-changing regulatory RNAs that bind chemicals and regulate gene
expression, directly coupling sensing to cellular actuation. However, it remains unclear how …

Using flux theory in dynamic omics data sets to identify differentially changing signals using DPoP

H Edwards, J Zavorskas, W Huso, AG Doan… - BMC …, 2024 - Springer
Background Derivative profiling is a novel approach to identify differential signals from dynamic
omics data sets. This approach applies variable step-size differentiation to time dynamic …

Discovery of treatment for nerve agents targeting a new metabolic pathway

…, RW Moretz, R Dorsey, MR Marten, W Huso… - Archives of …, 2020 - Springer
The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action
for chemical warfare agents. Recently, there have been numerous reports suggesting that …

Dynamic transcriptomic and phosphoproteomic analysis during cell wall stress in Aspergillus nidulans

C Chelius, W Huso, S Reese, A Doan, S Lincoln… - Molecular & Cellular …, 2020 - ASBMB
The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to
environmental stress to enable wall repair and resumption of normal growth. This complex, …

Phosphoproteomic and transcriptomic analyses reveal multiple functions for Aspergillus nidulans MpkA independent of cell wall stress

CL Chelius, LFC Ribeiro, W Huso, J Kumar… - Fungal Genetics and …, 2019 - Elsevier
The protein kinase MpkA plays a prominent role in the cell wall integrity signaling (CWIS)
pathway, acting as the terminal MAPK activating expression of genes which encode cell wall …

Aspergillus nidulans septa are indispensable for surviving cell wall stress

RN Spence, W Huso, H Edwards, A Doan… - Microbiology …, 2022 - Am Soc Microbiol
Septation in filamentous fungi is a normal part of development, which involves the formation
of cross-hyphal bulkheads, typically containing pores, allowing cytoplasmic streaming …

Protein Kinases MpkA and SepH Transduce Crosstalk Between CWI and SIN Pathways to Activate Protective Hyphal Septation Under Echinocandin Cell Wall Stress

…, MS Quintanilla, ME Morse, H Edwards, W Huso… - bioRxiv, 2024 - biorxiv.org
This study investigates a previously unreported stress signal transduced as crosstalk
between the Cell Wall Integrity (CWI) pathway and the Septation Initiation Network (SIN). …

Aspergillus nidulans cell wall integrity kinase, MpkA, impacts cellular phenotypes that alter mycelial-material mechanical properties

K Gray, H Edwards, AG Doan, W Huso, JH Lee, W Pan… - bioRxiv, 2024 - biorxiv.org
Mycelial materials are an emerging, natural material made from filamentous fungi that have
the potential to replace unsustainable materials used in numerous commercial applications (…

Aspergillus nidulans Transcription Factor BrlA is Utilized in a Conidiation-Independent Response to Cell-Wall Stress

H Edwards, J Zavorskas, W Huso, AG Doan, JH Lee… - bioRxiv, 2024 - biorxiv.org
The Aspergillus nidulans transcription factor BrlA is widely accepted as a master regulator
of conidiation. Under synchronized conidiation, over 2500 gene products show differential …

Optical transitions and multiphonon Raman scattering of Cu doped ZnO and MgZnO ceramics

…, J Mitchell, E Casey, H Hoeck, C Walker… - Applied Physics …, 2009 - pubs.aip.org
Cu doped ZnO and MgZnO ceramics were created via a process of cold pressing and
annealing, and their optical properties and phonon dynamics were studied. It was found that the …