A six-lobed membrane spanning cellulose synthesis complex (CSC) containing multiple
cellulose synthase (CESA) glycosyltransferases mediates cellulose microfibril formation. The …

A cellulose synthesis complex with a “rosette” shape is responsible for synthesis of cellulose
chains and their assembly into microfibrils within the cell walls of land plants and their …

The Macromolecular Neutron Diffractometer (MaNDi) is located on beamline 11B of the
Spallation Neutron Source at Oak Ridge National Laboratory. The instrument is a neutron time-of…

Introduction The Fc region of monoclonal antibodies (mAbs) interacts with the CD16a
receptor on natural killer (NK) cells with “low affinity” and “low selectivity”. This low affinity/…

Potassium ion channels utilize a highly selective filter to rapidly transport K + ions across
cellular membranes. This selectivity filter is composed of four binding sites which display almost …

The catalytic mechanism of class A β-lactamases is often debated due in part to the large
number of amino acids that interact with bound β-lactam substrates. The role and function of …

Neutron crystallography offers enormous potential to complement structures from X-ray
crystallography by clarifying the positions of low-Z elements, namely hydrogen. Macromolecular …

The monobactam antibiotic aztreonam is used to treat cystic fibrosis patients with chronic
pulmonary infections colonized by Pseudomonas aeruginosa strains expressing CTX-M …

The emergence and dissemination of bacterial resistance to β-lactam antibiotics via β-lactamase
enzymes is a serious problem in clinical settings, often leaving few treatment options for …

Higher plants synthesize cellulose using membrane-bound, six-lobed cellulose synthase
complexes, each lobe containing trimeric cellulose synthases (CESAs). Although molecular …