User profiles for Thoralf Opitz
 | Thoralf OpitzSenior Postdoc, Institute of Experimental Epileptology and Cognition Research, University of … Verified email at uni-bonn.de Cited by 4327 |
[HTML][HTML] Direct conversion of fibroblasts into stably expandable neural stem cells
Recent advances have suggested that direct induction of neural stem cells (NSCs) could
provide an alternative to derivation from somatic tissues or pluripotent cells. Here we show …
provide an alternative to derivation from somatic tissues or pluripotent cells. Here we show …
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
An intriguing question in human embryonic stem cell (hESC) biology is whether these pluripotent
cells can give rise to stably expandable somatic stem cells, which are still amenable to …
cells can give rise to stably expandable somatic stem cells, which are still amenable to …
Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil
…, EM Aronica, DM Rosenbaum, T Opitz… - Journal of …, 1997 - Soc Neuroscience
Transient, severe forebrain or global ischemia leads to delayed cell death of pyramidal
neurons in the hippocampal CA1. The precise molecular mechanisms underlying neuronal cell …
neurons in the hippocampal CA1. The precise molecular mechanisms underlying neuronal cell …
Inhibition of notch signaling in human embryonic stem cell–derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and …
L Borghese, D Dolezalova, T Opitz, S Haupt… - Stem …, 2010 - academic.oup.com
The controlled in vitro differentiation of human embryonic stem cells (hESCs) and other
pluripotent stem cells provides interesting prospects for generating large numbers of human …
pluripotent stem cells provides interesting prospects for generating large numbers of human …
Transcriptional upregulation of Cav3. 2 mediates epileptogenesis in the pilocarpine model of epilepsy
AJ Becker, J Pitsch, D Sochivko, T Opitz… - Journal of …, 2008 - Soc Neuroscience
In both humans and animals, an insult to the brain can lead, after a variable latent period, to
the appearance of spontaneous epileptic seizures that persist for life. The underlying …
the appearance of spontaneous epileptic seizures that persist for life. The underlying …
mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C
Potentiation of ionotropic glutamate receptor activity by metabotropic glutamate receptors (mGluRs)
is thought to modulate activity at glutamatergic synapses in the hippocampus. …
is thought to modulate activity at glutamatergic synapses in the hippocampus. …
Spontaneous development of synchronous oscillatory activity during maturation of cortical networks in vitro
T Opitz, AD De Lima, T Voigt - Journal of neurophysiology, 2002 - journals.physiology.org
Recent studies have focused attention on mechanisms of spontaneous large-scale
wavelike activity during early development of the neocortex. In this study, we describe and …
wavelike activity during early development of the neocortex. In this study, we describe and …
Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death
SY Grooms, T Opitz, MVL Bennett… - Proceedings of the …, 2000 - National Acad Sciences
Kainic acid (KA)-induced status epilepticus in adult rats leads to delayed, selective death of
pyramidal neurons in the hippocampal CA1 and CA3. Death is preceded by down-regulation …
pyramidal neurons in the hippocampal CA1 and CA3. Death is preceded by down-regulation …
An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus
…, M Royeck, D Sochivko, T Opitz… - Journal of …, 2011 - journals.physiology.org
Brain damage causes multiple changes in synaptic function and intrinsic properties of surviving
neurons, leading to the development of chronic epilepsy. In the widely used pilocarpine–…
neurons, leading to the development of chronic epilepsy. In the widely used pilocarpine–…
Synchronous oscillatory activity in immature cortical network is driven by GABAergic preplate neurons
T Voigt, T Opitz, AD de Lima - Journal of Neuroscience, 2001 - Soc Neuroscience
Neurons dissociated from embryonic cerebral rat cortex form a differentiated network of synaptic
connections and develop synchronous oscillatory network activity with the beginning of …
connections and develop synchronous oscillatory network activity with the beginning of …