The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The …

Simple Summary Circular RNAs (circRNAs) belong to a new class of non-coding RNAs
implicated in cellular physiological functions but also in the evolution of various human …

The p53 gene family members p53, p73, and p63 display several isoforms derived from the
presence of internal promoters and alternative splicing events. They are structural homologs …

This article investigates the mechanistic aspects of mutant p53 "gain of function" in
response to DNA damage. We show that mutant forms of p53 protein interact with NF-Y. The …

p73 has been identified as a structural and functional homolog of the tumor suppressor p53.
The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to …

In response to DNA damage, p53 activates G 1 /S blocking and apoptotic genes through
sequence-specific binding. p53 also represses genes with no target site, such as those for Cdc2 …

Mutant p53 proteins are present in more than half of human cancers. Yes‐associated protein
( YAP ) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and …

Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths
worldwide; PDAC is characterized by poor prognosis, resistance to conventional chemotherapy …

Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here,
we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring …

In vitro addition of stem cell factor (SCF) to c-kit-expressing A 1 –A 4 spermatogonia from
prepuberal mice stimulates their progression into the mitotic cell cycle and significantly reduces …